Paxilllin is a multifunctional and multidomain focal adhesion adapter protein which serves
an important scaffolding role at focal adhesions by recruiting structural and signaling …

Paxillin is a multi-domain scaffold protein that localizes to the intracellular surface of sites of
cell adhesion to the extracellular matrix. Through the interactions of its multiple protein …

The innate immune system of insects is divided into humoral defenses that include the
production of soluble effector molecules and cellular defenses like phagocytosis and …

Continuous adhesion formation and disassembly (adhesion turnover) in the protrusions of
migrating cells is regulated by unclear mechanisms. We show that p21-activated kinase …

The histopathological hallmarks of Alzheimer disease are the extracellular amyloid plaques,
composed principally of the amyloid beta peptide, and the intracellular neurofibrillary …

Reorganization of the actin cytoskeleton is essential for cellular processes during animal
development. Cofilin and actin depolymerizing factor (ADF) are potent actin‐binding …

Deposition of fibrillar amyloid β (fAβ) plays a critical role in Alzheimer's disease (AD). We
have shown recently that fAβ-induced dystrophy requires the activation of focal adhesion …

The cellular immune response of insects refers to defense responses mediated by
hemocytes such as phagocytosis, encapsulation, and clotting. In this chapter I review the …

We have established that HCMV acts as a specific ligand engaging and activating cellular
integrins on monocytes. As a result, integrin signaling via Src activation leads to the …

During development, Schwann cells (SCs) interpret different extracellular cues to regulate
their migration, proliferation, and the remarkable morphological changes associated with the …