Developing a prototype pathogen plan and research priorities for the alphaviruses

AM Powers, LE Williamson… - The Journal of …, 2023 - academic.oup.com
Abstract The Togaviridae family, genus, Alphavirus, includes several mosquito-borne human
pathogens with the potential to spread to near pandemic proportions. Most of these are …

Protective antibodies against Eastern equine encephalitis virus bind to epitopes in domains A and B of the E2 glycoprotein

AS Kim, SK Austin, CL Gardner, A Zuiani… - Nature …, 2019 - nature.com
Eastern equine encephalitis virus (EEEV) is a mosquito-transmitted alphavirus with a high
case mortality rate in humans. EEEV is a biodefence concern because of its potential for …

Human antibodies protect against aerosolized eastern equine encephalitis virus infection

LE Williamson, T Gilliland, PK Yadav, E Binshtein… - Cell, 2020 - cell.com
Eastern equine encephalitis virus (EEEV) is one of the most virulent viruses endemic to
North America. No licensed vaccines or antiviral therapeutics are available to combat this …

The structure of barmah forest virus as revealed by cryo-electron microscopy at a 6-angstrom resolution has detailed transmembrane protein architecture and …

VA Kostyuchenko, J Jakana, X Liu, AD Haddow… - Journal of …, 2011 - Am Soc Microbiol
Barmah Forest virus (BFV) is a mosquito-borne alphavirus that infects humans. A 6-Å-
resolution cryo-electron microscopy three-dimensional structure of BFV exhibits a typical …

Genetic targets for the detection and identification of Venezuelan equine encephalitis viruses

G Brightwell, JM Brown, DM Coates - Archives of virology, 1998 - Springer
Rt-PCR probes targeted to different gene sequences of VEE (Venezuelan equine
encephalitis) virus strain TC-83 were assessed for their sensitivity, specificity and non …

The Structural Biology of Eastern Equine Encephalitis Virus, an Emerging Viral Threat

SS Hasan, D Dey, S Singh, M Martin - Pathogens, 2021 - mdpi.com
Alphaviruses are arboviruses that cause arthritis and encephalitis in humans. Eastern
Equine Encephalitis Virus (EEEV) is a mosquito-transmitted alphavirus that is implicated in …

Genetic determinants of Sindbis virus strain TR339 affecting midgut infection in the mosquito Aedes aegypti

DJ Pierro, EL Powers, KE Olson - Journal of general …, 2007 - microbiologyresearch.org
Mosquito midgut epithelial cells (MEC) play a major role in determining whether an
arbovirus can successfully infect and be transmitted by mosquitoes. The Sindbis virus (SINV) …

Exposing cryptic epitopes on the Venezuelan equine encephalitis virus E1 glycoprotein prior to treatment with alphavirus cross-reactive monoclonal antibody allows …

AE Calvert, SL Bennett, AR Hunt, RH Fong, BJ Doranz… - Virology, 2022 - Elsevier
Eastern equine encephalitis virus (EEEV), western equine encephalitis virus (WEEV) and
Venezuelan equine encephalitis virus (VEEV) can cause fatal encephalitis in humans and …

Phage display identifies an Eastern equine encephalitis virus glycoprotein E2-specific B cell epitope

J Zhao, EC Sun, NH Liu, T Yang, QY Xu, YL Qin… - Veterinary immunology …, 2012 - Elsevier
The present study identified a linear B-cell epitope in the Eastern equine encephalitis virus
(EEEV) E2 glycoprotein by screening a phage-displayed random 12-mer peptide library …

Analysis of murine B-cell epitopes on Eastern equine encephalitis virus glycoprotein E2

S EnCheng, Z Jing, Y Tao, X QingYuan… - Applied microbiology …, 2013 - Springer
The Eastern equine encephalitis virus (EEEV) E2 protein is one of the main targets of the
protective immune response against EEEV. Although some efforts have done to elaborate …