Background Drug-induced liver injury (DILI) is the most challenging and thought-provoking
liver problem for hepatologists owing to unregulated medication usage in medical practices …

The liver is the center for drug and xenobiotic metabolism, which is influenced most with
medication/xenobiotic-mediated toxic activity. Drug-induced hepatotoxicity is common and …

Background Hepato-and nephrotoxicity of fluoride have been demonstrated in animals, but
few studies have examined potential effects in humans. This population-based study …

Fluoride is an element with toxic properties and has been proven to have some adverse
effects on many soft tissues, including brain tissue. This study aims to evaluate the protective …

Being the most essential organ in the body, the liver performs critical functions. Hepatic
disorders, such as alcoholic liver disease, hepatic steatosis, liver fibrosis, nonalcoholic fatty …

Fluoride (F), one of the most toxic environmental and industrial pollutants, is known to exert
hepatotoxicity. The contribution of oxidative stress to the F tolerance of liver remains largely …

Excessive fluoride intake has been reported to cause toxicities to brain, thyroid, kidney, liver
and testis tissues. Hesperidin (HSP) is an antioxidant that possesses anti-allergenic, anti …

Vitis vinifera (grape) is one of the “most‐produced fruit” in the world. Grape seeds are a
valuable source of phenolic compounds including resveratrol (RSV). Grape and one of its …

Excess fluoride (F) exposure can cause oxidative stress in the kidney. As an antioxidant,
selenium (Se) can potentially protect the kidney from F-induced injury in rats. Hence, the …

Fluoride compounds are abundant and widely distributed in the environment at a variety of
concentrations. Further, fluoride induces toxic effects in target organs such as the liver. In …