Schlafen 11 (SLFN11), a restriction factor for replicative stress induced by DNA-targeting anti-cancer therapies
Abstract Schlafen 11 (SLFN11) sensitizes cells to a broad range of anti-cancer drugs
including platinum derivatives (cisplatin and carboplatin), inhibitors of topoisomerases …
including platinum derivatives (cisplatin and carboplatin), inhibitors of topoisomerases …
CellMiner Cross-Database (CellMinerCDB) version 1.2: Exploration of patient-derived cancer cell line pharmacogenomics
Abstract CellMiner Cross-Database (CellMinerCDB, discover. nci. nih. gov/cellminercdb)
allows integration and analysis of molecular and pharmacological data within and across …
allows integration and analysis of molecular and pharmacological data within and across …
Targeting DNA repair and replication stress in the treatment of ovarian cancer
J Murai - International journal of clinical oncology, 2017 - Springer
Approximately half of high-grade serous epithelial ovarian cancers incur alterations in genes
of homologous recombination (BRCA1, BRCA2, RAD51C, Fanconi anemia genes), and the …
of homologous recombination (BRCA1, BRCA2, RAD51C, Fanconi anemia genes), and the …
Inhibiting the system xC−/glutathione axis selectively targets cancers with mutant-p53 accumulation
TP53, a critical tumour suppressor gene, is mutated in over half of all cancers resulting in
mutant-p53 protein accumulation and poor patient survival. Therapeutic strategies to target …
mutant-p53 protein accumulation and poor patient survival. Therapeutic strategies to target …
[HTML][HTML] Resistance to PARP inhibitors by SLFN11 inactivation can be overcome by ATR inhibition
Poly (ADP-ribose) polymerase inhibitors (PARPIs) kill cancer cells by trapping PARP1 and
PARP2. Talazoparib, the most potent PARPI inhibitor (PARPI), exhibits remarkable …
PARP2. Talazoparib, the most potent PARPI inhibitor (PARPI), exhibits remarkable …
CellMinerCDB for integrative cross-database genomics and pharmacogenomics analyses of cancer cell lines
CellMinerCDB provides a web-based resource (https://discover. nci. nih. gov/cellminercdb/)
for integrating multiple forms of pharmacological and genomic analyses, and unifying the …
for integrating multiple forms of pharmacological and genomic analyses, and unifying the …
A novel prognostic mRNA/miRNA signature for esophageal cancer and its immune landscape in cancer progression
Y Zhao, L Xu, X Wang, S Niu, H Chen… - Molecular …, 2021 - Wiley Online Library
Mounting evidence shows that MicroRNAs (miRNAs) and their target genes are aberrantly
expressed in many cancers and are linked to tumor occurrence and progression, especially …
expressed in many cancers and are linked to tumor occurrence and progression, especially …
[HTML][HTML] ONC201 kills breast cancer cells in vitro by targeting mitochondria
YE Greer, N Porat-Shliom, K Nagashima, C Stuelten… - Oncotarget, 2018 - ncbi.nlm.nih.gov
We report a novel mechanism of action of ONC201 as a mitochondria-targeting drug in
cancer cells. ONC201 was originally identified as a small molecule that induces transcription …
cancer cells. ONC201 was originally identified as a small molecule that induces transcription …
Auranofin/vitamin C: a novel drug combination targeting triple-negative breast cancer
E Hatem, S Azzi, N El Banna, T He… - JNCI: Journal of the …, 2019 - academic.oup.com
Background Cancer cells from different origins exhibit various basal redox statuses and thus
respond differently to intrinsic or extrinsic oxidative stress. These intricate characteristics …
respond differently to intrinsic or extrinsic oxidative stress. These intricate characteristics …
[HTML][HTML] Sensitivity of mesothelioma cells to PARP inhibitors is not dependent on BAP1 but is enhanced by temozolomide in cells with high-schlafen 11 and low-O6 …
D Rathkey, M Khanal, J Murai, J Zhang… - Journal of Thoracic …, 2020 - Elsevier
Abstract Introduction BRCA1-associated protein-1 (BAP1), a nuclear deubiquitinase thought
to be involved in DNA double-strand break repair, is frequently mutated in mesothelioma …
to be involved in DNA double-strand break repair, is frequently mutated in mesothelioma …