Background The hepatitis C virus (HCV) is a major public health problem and a leading
cause of chronic liver disease. In the United States, the Centers for Disease Control and …

This brief perspective article focuses on the most common errors and pitfalls, as well as the
do's and don'ts in drug combination studies, in terms of experimental design, data …

Established for 20 years as the definitive virology reference, the two-volume classic Fields
Virology is in its thoroughly revised, updated Fifth Edition. More than 100 world-renowned …

The nucleoside analogue ribavirin has antiviral activity against many distinct viruses both in
vitro and in vivo. Five distinct mechanisms have been proposed to explain the antiviral …

Nearly four generations of investigators have studied combined drug effects. Their methods
of generating and analyzing data have changed dramatically over the years but the basic …

Background Chronic hepatitis C virus (HCV) infection is a cause of major complications in
persons who are also infected with the human immunodeficiency virus (HIV). However, the …

The development of antiretroviral therapy against acquired immunodeficiency syndrome
(AIDS) has been an intense research effort since the discovery of the causative agent …

This brief review provides a practical guide for drug combination studies and delineates its
essence in terms of the mass-action-based theory, experimental design and automated …

Because of shared routes of transmission, hepatitis C virus (HCV) infection is common in
HIV-infected persons, who have been experiencing increasing HCV-related morbidity and …

Drug combinations may exhibit synergistic or antagonistic effects. Rational design of
synergistic drug combinations remains a challenge despite active experimental and …