Viral quasispecies evolution upon long-term virus replication in a noncoevolving cellular
environment raises relevant general issues, such as the attainment of population …

Background Despite the high sustained virological response rates achieved with current
directly-acting antiviral agents (DAAs) against hepatitis C virus (HCV), around 5–10% of …

Lethal mutagenesis is an antiviral approach that consists of extinguishing a virus by an
excess of mutations acquired during replication in the presence of a mutagenic agent, often …

Hepatitis C virus (HCV) remains a significant global health challenge, affecting millions of
people worldwide, with chronic infection a persistent threat. Despite the advent of direct …

Hepatitis C Virus (HCV) infection treatment has dramatically changed with the advent of
direct‐acting antiviral agents (DAAs). However, the efficacy of DAAs can be attenuated by …

This study aimed to assess the prevalence of natural resistance-associated substitutions
(RASs) to NS3, NS5A and NS5B inhibitors in 86 genotype 1 Hepatitis C Virus (HCV) …

Like many viruses, Hepatitis C Virus (HCV) has a high mutation rate, which helps the virus
adapt quickly, but mutations come with fitness costs. Fitness costs can be studied by different …

Incorporation of direct acting antivirals (DAA) in the treatment of Hepatitis C Virus (HCV)
significantly increases sustained virologic response rates. However, despite the greater …

The aim of this study was to compare efficacy and safety of different combination regimens in
re-treatment of HCV in the setting of inaccessibility of resistance testing. This real-life …

Medical interventions to prevent and treat viral disease constitute evolutionary forces that
may modify the genetic composition of viral populations that replicate in an infected host and …