Chronic pain is a maladaptive neurological disease that remains a major health problem. A
deepening of our knowledge on mechanisms that cause pain is a prerequisite to developing …

Chemotherapy-induced peripheral neuropathy (CIPN) is one of the most prevalent and
difficult-to-treat symptoms in cancer patients. For this reason, the explore for unused helpful …

Rutin is a natural anti-inflammatory ingredient widely found in medicinal plants. Studies
have shown that rutin inhibits mast cell degranulation and the release of inflammatory …

Background: Salvia circinata is an endemic species of Mexico used in the folk medicine of
Santiago Huauclilla, Oaxaca, mainly as remedy for gastrointestinal diseases. Hypothesis: If …

Aim/Background The combination of drugs with different mechanisms of action could be
more effective due to an enhanced synergistic activity. The pharmacological interactions …

Many clinical diseases are accompanied by the symptoms of pain, and the degree of pain is
closely related to the patients' suffering. Therefore, effectively relieving pain has become one …

Recently, the usage of zebrafish for pain studies has increased in the past years, especially
due to its robust pain-stimulated behaviors. Fin amputation has been demonstrated to …

Abstract Senna septemtrionalis (Viv.) HS Irwin & Barneby (Fabaceae) is a medicinal plant
used as a folk remedy for inflammation and pain. The objective of this study was to evaluate …

Background/Objectives: Alzheimer's disease (AD) is an age-related degenerative brain
disorder characterized by a progressive decline in cognitive function and memory. This …

The l-arginine (l-Arg)/nitric oxide/cyclic GMP/potassium channel (K ATP) pathway and opioid
receptors are known to play critical roles in pain perception and the antinociceptive effects of …