Organic sonosensitizers for sonodynamic therapy: from small molecules and nanoparticles toward clinical development

D Li, Y Yang, D Li, J Pan, C Chu, G Liu - Small, 2021 - Wiley Online Library
Sonodynamic therapy (SDT) is a novel noninvasive therapeutic modality that combines low‐
intensity ultrasound and sonosensitizers. Versus photo‐mediated therapy, SDT has the …

Potential role of flavivirus NS2B-NS3 proteases in viral pathogenesis and anti-flavivirus drug discovery employing animal cells and models: a review

A Wahaab, BE Mustafa, M Hameed, NJ Stevenson… - Viruses, 2021 - mdpi.com
Flaviviruses are known to cause a variety of diseases in humans in different parts of the
world. There are very limited numbers of antivirals to combat flavivirus infection, and …

Japanese Encephalitis Virus: an update on the potential antivirals and vaccines

KS Srivastava, V Jeswani, N Pal, B Bohra… - Vaccines, 2023 - mdpi.com
Japanese encephalitis virus (JEV) is the causal agent behind Japanese encephalitis (JE), a
potentially severe brain infection that spreads through mosquito bites. JE is predominant …

Review of emerging Japanese encephalitis virus: new aspects and concepts about entry into the brain and inter-cellular spreading

L Filgueira, N Lannes - Pathogens, 2019 - mdpi.com
Japanese encephalitis virus (JEV) is an emerging flavivirus of the Asia-Pacific region. More
than two billion people live in endemic or epidemic areas and are at risk of infection …

Proline-based allosteric inhibitors of Zika and Dengue virus NS2B/NS3 proteases

B Millies, F von Hammerstein, A Gellert… - Journal of medicinal …, 2019 - ACS Publications
The NS2B/NS3 serine proteases of the Zika and Dengue flaviviruses are attractive targets
for the development of antiviral drugs. We report the synthesis and evaluation of a new …

Inhibitors of the Zika virus protease NS2B-NS3

S Voss, C Nitsche - Bioorganic & medicinal chemistry letters, 2020 - Elsevier
In recent years, the Zika virus has emerged from a neglected flavivirus to a health-
threatening pathogen that causes epidemic outbreaks associated with neurological …

CRISPR-Cas13a cleavage of dengue virus NS3 gene efficiently inhibits viral replication

H Li, S Wang, X Dong, Q Li, M Li, J Li, Y Guo… - … Therapy-Nucleic Acids, 2020 - cell.com
The CRISPR-Cas9 system has been applied to DNA editing with precision in eukaryotic and
prokaryotic systems, but it is unable to edit RNA directly. A recently developed CRISPR …

Therapeutics for flaviviral infections

AM Bifani, KWK Chan, D Borrenberghs, MJA Tan… - Antiviral Research, 2023 - Elsevier
Flaviviruses are vector-borne pathogens capable of causing devastating human diseases.
The re-emergence of Zika in 2016 notoriously led to a widescale epidemic in the Americas …

Drug repurposing: A strategy for discovering inhibitors against emerging viral infections

IJ dos Santos Nascimento… - Current Medicinal …, 2021 - ingentaconnect.com
Background: Viral diseases are responsible for several deaths around the world. Over the
past few years, the world has seen several outbreaks caused by viral diseases that, for a …

Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors

RPM Abrams, A Yasgar, T Teramoto… - Proceedings of the …, 2020 - National Acad Sciences
When Zika virus emerged as a public health emergency there were no drugs or vaccines
approved for its prevention or treatment. We used a high-throughput screen for Zika virus …