The impact of chromosomal rearrangements in speciation: from micro-to macroevolution

K Lucek, MD Giménez, M Joron… - Cold Spring …, 2023 - cshperspectives.cshlp.org
Chromosomal rearrangements (CRs) have been known since almost the beginning of
genetics. While an important role for CRs in speciation has been suggested, evidence …

A holocentric twist to chromosomal speciation?

K Lucek, H Augustijnen, M Escudero - Trends in Ecology & Evolution, 2022 - cell.com
Chromosomal rearrangements trigger speciation by acting as barriers to gene flow.
However, the underlying theory was developed with monocentric chromosomes in mind …

Modular safe-harbor transgene insertion for targeted single-copy and extrachromosomal array integration in Caenorhabditis elegans

S El Mouridi, F Alkhaldi, C Frøkjær-Jensen - G3, 2022 - academic.oup.com
Efficient and reproducible transgenesis facilitates and accelerates research using genetic
model organisms. Here, we describe a mo dular s afe-harbor t ransgene i nsertion (MosTI) …

Nematode chromosomes

PM Carlton, RE Davis, S Ahmed - Genetics, 2022 - academic.oup.com
The nematode Caenorhabditis elegans has shed light on many aspects of eukaryotic
biology, including genetics, development, cell biology, and genomics. A major factor in the …

Centromeric and pericentric transcription and transcripts: their intricate relationships, regulation, and functions

J Zhu, Q Guo, M Choi, Z Liang, KWY Yuen - Chromosoma, 2023 - Springer
Centromeres are no longer considered to be silent. Both centromeric and pericentric
transcription have been discovered, and their RNA transcripts have been characterized and …

High-throughput library transgenesis in Caenorhabditis elegans via Transgenic Arrays Resulting in Diversity of Integrated Sequences (TARDIS)

ZC Stevenson, MJ Moerdyk-Schauwecker, SA Banse… - Elife, 2023 - elifesciences.org
High-throughput transgenesis using synthetic DNA libraries is a powerful method for
systematically exploring genetic function. Diverse synthesized libraries have been used for …

Argonaute protein CSR-1 restricts localization of holocentromere protein HCP-3, the C. elegans CENP-A homolog

CYY Wong, HN Tsui, Y Wang… - Journal of Cell …, 2024 - journals.biologists.com
Chromosome segregation errors caused by centromere malfunction can lead to
chromosome instability and aneuploidy. In Caenorhabditis elegans, the Argonaute protein …

[HTML][HTML] The roles of transcription, chromatin organisation and chromosomal processes in holocentromere establishment and maintenance

Y Wang, L Wu, KWY Yuen - Seminars in Cell & Developmental Biology, 2022 - Elsevier
The centromere is a unique functional region on each eukaryotic chromosome where the
kinetochore assembles and orchestrates microtubule attachment and chromosome …

[PDF][PDF] Recurrent but Short-Lived Duplications of Centromeric Proteins in Holocentric Caenorhabditis Species

L Caro, P Raman, FA Steiner, M Ailion… - Molecular biology and …, 2022 - academic.oup.com
Centromeric histones (CenH3s) are essential for chromosome inheritance during cell
division in most eukaryotes. CenH3 genes have rapidly evolved and undergone repeated …

CSR-1 RNA interference pathway restricts holocentromere protein CENP-A/HCP-3 localization in Caenorhabditis elegans

CY Yu Wong, KW Yee Yuen - bioRxiv, 2022 - biorxiv.org
CSR-1 is an argonaute of a RNA interference pathway that is important for chromosome
segregation in C. elegans. Live-cell imaging revealed that CSR-1 depletion slows down …