The fundamental defect (s) that drives atopic dermatitis (AD) remains controversial.“Outside
in” proponents point to the important association of filaggrin gene mutations and other skin …

Notch signaling orchestrates the regulation of cell proliferation, differentiation, migration and
apoptosis of epidermal cells by strictly interacting with other cellular pathways. Any …

Psoriasis is a T cells mediated chronic skin inflammation in which helper T (Th) cells play in
critical roles in its pathogenesis. Taxifolin (TXL) has been discovered to exert various …

Purpose. To evaluate the regulating effect of Notch1 signaling on Th17/Treg immune
imbalance in psoriasis vulgaris (PV). Materials and Methods. Notch1, Hes‐1, RORγt, Foxp3 …

Psoriasis is characterized by hyperproliferation and defective differentiation of keratinocytes
(KCs). Patients with psoriasis are at a high risk of developing diabetes and cardiovascular …

Localization of each keratin isoform differs among epidermal layers. Proliferating basal cells
synthesize keratin 14 (K14) and suprabasal cells express keratin 10 (K10) in normal skin …

Psoriasis is a chronic inflammatory disease characterized by the abnormal differentiation
and hyperproliferation of epidermal keratinocytes. The aim of the present study was to …

Background Scalp psoriasis seriously affects the appearance and psychological status of
patients. The aim of this study was to investigate the effect and potential mechanism of RPL9 …

Aquaporin 3 (AQP3) is an aquaglyceroporin which transports water, glycerol and small
solutes across the plasma membrane. Its functions are not limited to fluid transport but also …

The aim of this study was twofold:(1) evaluate the effect of benzo [a] pyrene (BaP) on
expression levels of AQP3 and Notch1 genes in HaCaT cells exposed “in vitro” and (2) …