Progress in the field of precision medicine has changed the landscape of cancer therapy.
Precision medicine is propelled by technologies that enable molecular profiling, genomic …

Hyaluronic acid (HA) is a linear polysaccharide and crucial component of the extracellular
matrix (ECM), maintaining tissue hydration and tension. Moreover, HA contributes to …

The mTOR complex 1 (mTORC1) pathway promotes cell growth in response to many cues,
including amino acids, which act through the Rag guanosine triphosphatases (GTPases) to …

A new pathway of intermediary metabolism is described involving the catabolism of
hyaluronan. The cell surface hyaluronan receptor, CD44, two hyaluronidases, Hyal-1 and …

The past decade has seen great strides in our understanding of the genetic basis of human
disease. Arguably, the most profound impact has been in the area of cancer genetics, where …

The Rag family of guanosine triphosphatases (GTPases) regulates eukaryotic cell growth in
response to amino acids by activating the target of rapamycin complex 1 (TORC1). In …

Autophagy is a process of cellular self-digestion induced by various forms of starvation.
Although nitrogen deficit is a common trigger, some yeast cells induce autophagy upon …

Hyaluronan is a negatively charged, high molecular weight glycosaminoglycan found
predominantly in the extracellular matrix. Intracellular locations for hyaluronan have also …

Loss of heterozygosity (LOH) involving several chromosome 3p regions accompanied by
chromosome 3p deletions are detected in almost 100% of small (SCLCs) and more than …

Lung cancer results from multiple changes in the genome of susceptible pulmonary cells
caused by exposure to carcinogens found in tobacco smoke, the environment, or the …