Fluorouracil (5-FU) has been an important anti-cancer drug to date. With an increase in the
knowledge of its mechanism of action, various treatment modalities have been developed …

Synchronous cell populations are commonly used for the analysis of various aspects of
cellular metabolism at specific stages of the cell cycle. Cell synchronization at a chosen cell …

The DNA damage response (DDR) is a series of pathways and processes required to repair
lesions to DNA. These pathways range from repairing strand breaks to the double helix …

Radiation therapy remains one of the most effective cancer treatments. Nevertheless,
biology-driven personalized radiation therapy that enables treatment according to the …

Uracil misincorporation during DNA replication is a major cell toxic event, of which cancer
cells overcome by activating the dUTPase enzyme. The DUT gene is the only known …

The elevated level of replication stress is an intrinsic characteristic of cancer cells. Targeting
the mechanisms that maintain genome stability to further increase replication stress and thus …

Telomerase, the end-replication enzyme, is reactivated in malignant cancers to drive cellular
immortality. While this distinction makes telomerase an attractive target for anti-cancer …

Purine and pyrimidine nucleotides are crucial building blocks for the survival of cells, and
there are layers of pathways to make sure a stable supply of them including de novo …

Many cancers have developed resistance to 5-FU, due to removal by the enzyme uracil-
DNA glycosylase (UDG), a type of base excision repair enzyme (BER) that can excise uracil …

Backgrounds: To identify diagnostic biomarkers for differentiating oral squamous cell
carcinoma (OSCC) from oral erosive lichen planus (OELP) and investigate potential …