Heart failure (HF) is a syndrome affecting all organ systems. While some organ interactions
have been studied intensively in HF (such as the cardiorenal interaction), the endocrine gut …

Secretin is a key hormone of the intestinal phase of digestion which activates pancreatic,
bile duct and Brunner gland HCO3− secretion. Recently, the secretin receptor (SCTR) was …

Background: Pulmonary hypertension (PH) can occur as a complication of schistosomiasis.
In humans, schistosomiasis-PH persists despite antihelminthic therapy and parasite …

The gut microbiota plays a vital role in maintaining gastrointestinal homeostasis, however,
whether it is influenced by gut hormones remains unknown. Secretin is a well-known …

The Secretin receptor (SCTR) presents a promising path for hypertension management, with
KSD179019 as identified as a Positive Allosteric Modulator (PAM) of SCTR, demonstrating …

Sympathetic overdrive plays a key role in the perturbation of cardiometabolic homeostasis.
Diet-induced and exercise-induced weight loss remains a key strategy to combat metabolic …

Background Cardiovascular diseases are prevalent worldwide with any age, and it is
characterized by sudden blockage of blood flow to heart and permanent damage to the …

Abstract The Secretin/Secretin receptor (SCTR) axis is well-known for its important role in
water/salt homeostasis and blood pressure control. Recent studies revealed that absence of …

Pulmonary hypertension (PH) is characterized by pulmonary vascular remodeling and
associated with adverse outcomes. In patients with PH, plasma aldosterone levels are …

Hypertrophic cardiomyopathy (HCM) is a global health problem characterized by left
ventricle become thick and stiff with effect of indication including chest pain, fluttering …