Protein lysine methylation is a crucial post-translational modification that regulates the
functions of both histone and non-histone proteins. Deregulation of the enzymes or 'writers' …

Nuclear receptor binding SET domain proteins (NSDs) catalyze the mono-or dimethylation
of histone 3 lysine 36 (H3K36me1 and H3K36me2), using S-adenosyl-l-methionine (SAM) …

Nuclear receptor-binding SET domain-containing 2 (NSD2) is the primary enzyme
responsible for the dimethylation of lysine 36 of histone 3 (H3K36), a mark associated with …

Sickle cell disease (SCD) is a heritable disorder caused by β-globin gene mutations.
Induction of fetal γ-globin is an established therapeutic strategy. Recently, epigenetic …

The CACHE challenges are a series of prospective benchmarking exercises to evaluate
progress in the field of computational hit-finding. Here we report the results of the inaugural …

The PR/SET domain family (PRDM) comprise a family of genes whose protein products
share a conserved N-terminal PR [PRDI-BF1 (positive regulatory domain I-binding factor 1) …

We herewith applied a priori a generic hit identification method (POEM) for difficult targets of
known three-dimensional structure, relying on the simple knowledge of physicochemical …

Histone lysine methylation is a post-translational modification that plays a key role in the
epigenetic regulation of a broad spectrum of biological processes. Moreover, the …

The Warburg effect‐related metabolic dysfunction of the tricarboxylic acid (TCA) cycle has
emerged as a hallmark of various solid tumors, particularly renal cell carcinoma (RCC). RCC …

Tumor cells show widespread genetic alterations that change the expression of genes
driving tumor progression, including genes that maintain genomic integrity. In recent years, it …