Cardiovascular disease remains the leading cause of morbidity and mortality in the
developed world. In recent decades, extraordinary effort has been devoted to defining the …

Genetically modified animals are vital for gaining a proper understanding of disease
mechanisms. Mice have long been the mainstay of basic research into a wide variety of …

Bovine and ovine embryos exposed to a variety of unusual environments prior to the
blastocyst stage have resulted in the development of unusually large offspring which can …

Entity or Function? specific adult stem cell may need to be expanded. Accordingly, adult
stem cells may not only act locally in the tissues in which they reside, but may also be …

In this study, we demonstrate the production of transgenic goats by nuclear transfer of fetal
somatic cells. Donor karyoplasts were obtained from a primary fetal somatic cell line derived …

The discovery of methods to convert somatic cells into induced pluripotent stem cells
(iPSCs) through expression of a small combination of transcription factors has raised the …

Eight calves were derived from differentiated cells of a single adult cow, five from cumulus
cells and three from oviductal cells out of 10 embryos transferred to surrogate cows (80 …

The use of pigs in neuroscience research has increased in the past decade, which has seen
broader recognition of the potential of pigs as an animal for experimental modeling of …

Pig cloning will have a marked impact on the optimization of meat production and
xenotransplantation. To clone pigs from differentiated cells, we microinjected the nuclei of …

The present invention provides for a method or methods of targeted genetic recombination
or mutagenesis in a host cell or organism, and compositions useful for carrying out the …