Sexually reproducing organisms rely on the precise reduction of chromosome number
during a specialized cell division called meiosis. Whereas mitosis produces diploid daughter …

The ability of cells to make exact replicas of themselves is central to the life and
development of complex organisms. Initial insights into the question of how cells divide …

The anaphase-promoting complex/cyclosome (APC/C) is a multisubunit E3 ubiquitin ligase
that triggers the degradation of multiple substrates during mitosis. Cdc20/Fizzy and …

The maternally expressed C. elegans gene spd-5 encodes a centrosomal protein with
multiple coiled-coil domains. During mitosis in mutants with reduced levels of SPD-5 …

Mitosis in metazoa requires nuclear envelope (NE) disassembly and reassembly. NE
disassembly is driven by multiple phosphorylation events. Mitotic phosphorylation of the …

The mechanisms governing centrosome duplication remain poorly understood. We
identified a gene called sas-4 that is essential for this process in C. elegans. SAS-4 encodes …

The C. elegans germ line proliferates from one primordial germ cell (PGC) set aside in the
early embryo to over a thousand cells in the adult. Most germline proliferation is controlled …

Accurate chromosome segregation during cell division requires not only the establishment,
but also the precise, regulated release of chromosome cohesion. Chromosome dynamics …

Disjunction of pairs of homologous chromosomes during the first meiotic division (MI)
requires anaphase-promoting complex (APC)-mediated activation of separase in budding …

Cell-division control affects many aspects of development. Caenorhabditis elegans cell-
cycle genes have been identified over the past decade, including at least two distinct Cyclin …