Since the demonstration of its involvement in cell proliferation, the eukaryotic initiation factor
5A (eIF5A) has been studied principally in relation to the development and progression of …

Introduction: Parasitic diseases that pose a threat to human life include leishmaniasis–
caused by protozoan parasite Leishmania species. Existing drugs have limitations due to …

Studies of Leishmania donovani have shown that both ornithine decarboxylase and
spermidine synthase, two enzymes of the polyamine biosynthetic pathway, are critical for …

Amino acid sensing is an intracellular function that supports nutrient homeostasis, largely
through controlled release of amino acids from lysosomal pools. The intracellular pathogen …

Parasites of the genus Leishmania cause a variety of devastating and often fatal diseases in
humans worldwide. Because a vaccine is not available and the currently small number of …

Polyamines are polycationic organic amines that are required for all eukaryotic life,
exemplified by the polyamine spermidine, which plays an essential role in translation. They …

Nanomedicine strategies were first adapted and successfully translated to clinical
application for diseases, such as cancer and diabetes. These strategies would no doubt …

Molecular therapy refers to targeted therapies based on molecules which have been
intelligently directed towards specific biomolecular structures and include small molecule …

Leishmaniasis is a tropical disease caused by a protozoan parasite Leishmania that is
transmitted via infected female sandflies. At present, leishmaniasis treatment mainly counts …

Leishmaniasis is a neglected disease affecting more than 12 million people worldwide. The
most used drugs are pentavalent antimonials that are very toxic and display the problem of …