Autism spectrum disorder (ASD) has a major impact on the development and social
integration of affected individuals and is the most heritable of psychiatric disorders. An …

The introduction of high-resolution time lapse imaging and molecular biological tools has
changed dramatically the rate of progress towards the understanding of the complex …

Dendritic spines are small actin-rich protrusions from neuronal dendrites that form the
postsynaptic part of most excitatory synapses and are major sites of information processing …

Mutations that cause intellectual disability (ID) and autism spectrum disorder (ASD) are
commonly found in genes that encode for synaptic proteins. However, it remains unclear …

Recent findings have significantly expanded our understanding of the regulation of actin-
depolymerizing factor (ADF)/cofilin proteins and the profound multifaceted impact that these …

Mutations in more than 450 different genes have been associated with intellectual disability
(ID) and related cognitive disorders (CDs), such as autism. It is to be expected that this …

Summary SynGAP is a Ras-GTPase activating protein highly enriched at excitatory
synapses in the brain. Previous studies have shown that CaMKII and the RAS-ERK pathway …

Accumulating data, including those from large genetic association studies, indicate that
alterations in glutamatergic synapse structure and function represent a common underlying …

SynGAP is a potent regulator of biochemical signaling in neurons and plays critical roles in
neuronal function. It was first identified in 1998, and has since been extensively …

De novo mutations in SYNGAP1, which codes for a RAS/RAP GTP‐activating protein, cause
nonsyndromic intellectual disability (NSID). All disease‐causing point mutations identified …