[HTML][HTML] Wound healing, fibroblast heterogeneity, and fibrosis
Fibroblasts are highly dynamic cells that play a central role in tissue repair and fibrosis.
However, the mechanisms by which they contribute to both physiologic and pathologic …
However, the mechanisms by which they contribute to both physiologic and pathologic …
The role of myofibroblasts in physiological and pathological tissue repair
Myofibroblasts are the construction workers of wound healing and repair damaged tissues
by producing and organizing collagen/extracellular matrix (ECM) into scar tissue. Scar tissue …
by producing and organizing collagen/extracellular matrix (ECM) into scar tissue. Scar tissue …
Chitosan/Hyaluronic acid/Alginate and an assorted polymers loaded with honey, plant, and marine compounds for progressive wound healing—Know-how
M Prasathkumar, S Sadhasivam - International Journal of Biological …, 2021 - Elsevier
Biomaterials are being extensively used in regenerative medicine including tissue
engineering applications, as these enhance tissue development, repair, and help in the …
engineering applications, as these enhance tissue development, repair, and help in the …
Down-Regulating Scar Formation by Microneedles Directly via a Mechanical Communication Pathway
Q Zhang, L Shi, H He, X Liu, Y Huang, D Xu, M Yao… - ACS …, 2022 - ACS Publications
Excessive extracellular matrix deposition drives fibroblasts into a state of high mechanical
stress, exacerbating pathological fibrosis and hypertrophic scar formation, leading to tissue …
stress, exacerbating pathological fibrosis and hypertrophic scar formation, leading to tissue …
[HTML][HTML] Hydrogel dressing integrating FAK inhibition and ROS scavenging for mechano-chemical treatment of atopic dermatitis
Atopic dermatitis (AD) is a chronic skin disease caused by skin immune dyshomeostasis and
accompanied by severe pruritus. Although oxidative stress and mechanical scratching can …
accompanied by severe pruritus. Although oxidative stress and mechanical scratching can …
[HTML][HTML] Hydrogel scaffolds to deliver cell therapies for wound healing
Cutaneous wounds are a growing global health burden as a result of an aging population
coupled with increasing incidence of diabetes, obesity, and cancer. Cell-based approaches …
coupled with increasing incidence of diabetes, obesity, and cancer. Cell-based approaches …
Disrupting mechanotransduction decreases fibrosis and contracture in split-thickness skin grafting
Burns and other traumatic injuries represent a substantial biomedical burden. The current
standard of care for deep injuries is autologous split-thickness skin grafting (STSG), which …
standard of care for deep injuries is autologous split-thickness skin grafting (STSG), which …
[HTML][HTML] Disrupting biological sensors of force promotes tissue regeneration in large organisms
Tissue repair and healing remain among the most complicated processes that occur during
postnatal life. Humans and other large organisms heal by forming fibrotic scar tissue with …
postnatal life. Humans and other large organisms heal by forming fibrotic scar tissue with …
ROS-scavenging hydrogel to accelerate wound healing and reduce scar formation
X Shu, J Shu, Y Wang, H Deng, J Zhang, J He… - Chemical Engineering …, 2023 - Elsevier
Both repair of chronic wounds and prevention of excessive scarring after skin trauma remain
great challenges, which can lead to psychological diseases and serious economic burden …
great challenges, which can lead to psychological diseases and serious economic burden …
Convergence of 3D printed biomimetic wound dressings and adult stem cell therapy
Biomimetically designed medical-grade polycaprolactone (mPCL) dressings are 3D-printed
with pore architecture and anisotropic mechanical characteristics that favor skin wound …
with pore architecture and anisotropic mechanical characteristics that favor skin wound …