Microglia, the resident immune cells of the central nervous system (CNS), are primarily
derived from the embryonic yolk sac and make their way to the CNS during early …

The complement system is increasingly recognized as a key player in the synapse loss and
cognitive impairments observed in Alzheimer's disease (AD). In particular, the process of …

Heterozygous mutations in the granulin (GRN) gene, resulting in the haploinsufficiency of
the progranulin (PGRN) protein, is a leading cause of frontotemporal lobar degeneration …

Progranulin is an evolutionarily conserved protein that has been implicated in human
neurodevelopmental and neurodegenerative diseases. Human progranulin is comprised of …

Background Parkinson's disease (PD) is a complex neurodegenerative disease with an
elusive etiology that involves the interaction between genetic, behavioral, and …

Progranulin (PGRN), which is produced in neurons and microglia, is a neurotrophic and anti-
inflammatory glycoprotein. Human loss-of-function mutations cause frontotemporal …

Background Alterations in progranulin (PGRN) expression are associated with multiple
neurodegenerative diseases (NDs), including frontotemporal dementia (FTD), Alzheimer's …

The capacity of immune cells to alter their function based on their metabolism is the basis of
the emerging field of immunometabolism. Microglia are the resident innate immune cells of …

Progranulin is a secreted pro-protein that has anti-inflammatory and neurotrophic effects and
is necessary for maintaining lysosomal function. Mutations in progranulin (GRN) are a major …

Mutations in the human granulin (GRN) gene are associated with multiple diseases,
including dementia disorders such as frontotemporal dementia (FTD) and limbic …