Several human pathogens are to be found within the bacterial genus Mycobacterium,
notably Mycobacterium tuberculosis, the causative agent of tuberculosis, one of the most …

About 300 of steroid drugs have been identified since the research and development to
steroid drugs was triggered in 1950's. Although much progress in microbial …

The lipidic envelope of Mycobacterium tuberculosis promotes virulence in many ways, so we
developed a lipidomics platform for a broad survey of cell walls. Here we report two new …

Recent advances in the study of mycobacterial lipids indicate that the class of outer
membrane lipids known as dimycocerosate esters (DIMs) are major virulence factors of …

Mycobacterium tuberculosis possesses a diversity of potential virulence factors including
complex branched lipids such as the phenolic glycolipid PGL-tb. PGL-tb expression by the …

The cell envelope of pathogenic mycobacteria is highly distinctive in that it contains a
number of lipids esterified with structurally related long-chain multi-methyl-branched fatty …

The success of Mycobacterium tuberculosis as a pathogen is well established: tuberculosis
is the leading cause of death by a single infectious agent worldwide. The threat of multi-and …

Background In the past decade, the availability of complete genome sequence data has
greatly facilitated comparative genomic research aimed at addressing genetic variability …

The compositional and architectural complexity of the mycobacterial cell envelope is
probably the most distinctive feature of the Mycobacterium genus. It is the basis of many of …

Over a decade ago, the analysis of the complete sequence of the genome of the human
pathogen Mycobacterium tuberculosis revealed an unexpectedly high number of open …