Background: Current guidelines recommend the use of a combination of inhaled β2 agonists
and anticholinergics, particularly for patients with acute severe or life threatening asthma in …

Background There are several treatment options for managing acute asthma exacerbations
(sustained worsening of symptoms that do not subside with regular treatment and require a …

Background Anticholinergic medications such as ipratropium improve the pulmonary
function of patients with acute exacerbations of asthma, but their effect on hospitalization …

About 10% of American children have asthma, and its prevalence, morbidity, and mortality
have been increasing. Asthma is an inflammatory disease with edema, bronchial …

We designed a larger, double-blind, randomized, prospective trial to test our hypothesis that
patients with acute asthma given combination high dose therapy with ipratropium bromide …

Study Objectives: Mechanical ventilation of patients with severe lower airway obstruction
presents significant risks; therefore, avoiding the intubation in these patients has been a …

Background Inhaled corticosteroids are effective in the treatment of children with asthma. It is
uncertain how inhaled corticosteroids compare with oral corticosteroids in the management …

The role for anticholinergic medications in acute asthma is not well-defined. Thus, the use of
therapy with anticholinergics and β 2-agonists, either simultaneously or in sequence, has …

Background The mainstay of treatment for acute asthma in children is nebulised β 2-
adrenergic agents such as salbutamol, given with corticosteroids. However, penetration of …

Background Inhaled anticholinergics given in addition to β 2‐agonists are effective in
reducing hospital admissions in children presenting to the emergency department with a …