Selenium is an essential micronutrient that plays a crucial role in development and a wide
variety of physiological processes including effect immune responses. The immune system …

The metastatic spread of malignant cells to distant anatomical locations is a prominent
cause of cancer-related death. Metastasis is governed by cancer-cell-intrinsic mechanisms …

MICA and MICB are expressed by many human cancers as a result of cellular stress, and
can tag cells for elimination by cytotoxic lymphocytes through natural killer group 2D …

The engineered expression of chimeric antigen receptors (CARs) on the surface of T cells
enables the redirection of T-cell specificity. Early clinical trials using CAR T cells for the …

Since the regulatory approval of ipilimumab in 2011, the field of cancer immunotherapy has
been experiencing a renaissance. This success is based on progress in both preclinical and …

During malignant transformation, accumulated somatic mutations endow cancer cells with
increased invasiveness and immunogenicity. Under selective pressure, these highly …

Background Immunotherapies still fail to benefit colorectal cancer (CRC) patients. Relevant
functional assays aimed at studying these failures and the efficacy of cancer immunotherapy …

Checkpoint blockade immunotherapy targeting the PD-1/PD-L1 inhibitory axis has produced
remarkable results in the treatment of several types of cancer. Whereas cytotoxic T cells are …

By fusing the extracellular domain of the natural killer (NK) cell receptor NKG2D to DAP12,
we constructed a chimeric antigen receptor (CAR) to improve NK cell tumor responses. An …

Simple Summary Innate immune natural killer (NK) cells are capable of killing metastatic
cancer cells without activation by antigen-presenting cells beforehand. The cytotoxic effects …