Molecular mechanisms of cardiac remodeling and regeneration in physical exercise
D Schüttler, S Clauss, LT Weckbach, S Brunner - Cells, 2019 - mdpi.com
Regular physical activity with aerobic and muscle-strengthening training protects against the
occurrence and progression of cardiovascular disease and can improve cardiac function in …
occurrence and progression of cardiovascular disease and can improve cardiac function in …
Biodiversity-based development and evolution: the emerging research systems in model and non-model organisms
Evolutionary developmental biology, or Evo-Devo for short, has become an established field
that, broadly speaking, seeks to understand how changes in development drive major …
that, broadly speaking, seeks to understand how changes in development drive major …
Single-cell transcriptome analysis maps the developmental track of the human heart
The heart is the central organ of the circulatory system, and its proper development is vital
for maintaining human life. Here, we used single-cell RNA sequencing to profile the gene …
for maintaining human life. Here, we used single-cell RNA sequencing to profile the gene …
Pkm2 regulates cardiomyocyte cell cycle and promotes cardiac regeneration
Background: The adult mammalian heart has limited regenerative capacity, mostly
attributable to postnatal cardiomyocyte cell cycle arrest. In the last 2 decades, numerous …
attributable to postnatal cardiomyocyte cell cycle arrest. In the last 2 decades, numerous …
[HTML][HTML] ALKBH5 regulates cardiomyocyte proliferation and heart regeneration by demethylating the mRNA of YTHDF1
Z Han, X Wang, Z Xu, Y Cao, R Gong, Y Yu, Y Yu… - Theranostics, 2021 - ncbi.nlm.nih.gov
Abstract N 6-methyladenosine (m 6 A) RNA modification, a dynamic and reversible process,
is essential for tissue development and pathogenesis. However, the potential involvement of …
is essential for tissue development and pathogenesis. However, the potential involvement of …
[HTML][HTML] A small-molecule cocktail promotes mammalian cardiomyocyte proliferation and heart regeneration
J Du, L Zheng, P Gao, H Yang, WJ Yang, F Guo… - Cell Stem Cell, 2022 - cell.com
Zebrafish and mammalian neonates possess robust cardiac regeneration via the induction
of endogenous cardiomyocyte (CM) proliferation, but adult mammalian hearts have very …
of endogenous cardiomyocyte (CM) proliferation, but adult mammalian hearts have very …
Non-coding RNA therapeutics for cardiac regeneration
A growing body of evidence indicates that cardiac regeneration after myocardial infarction
can be achieved by stimulating the endogenous capacity of cardiomyocytes (CMs) to …
can be achieved by stimulating the endogenous capacity of cardiomyocytes (CMs) to …
Midbody positioning and distance between daughter nuclei enable unequivocal identification of cardiomyocyte cell division in mice
M Hesse, M Doengi, A Becker, K Kimura… - Circulation …, 2018 - Am Heart Assoc
Rationale: New strategies in the field of cardiac regeneration are directed at identifying
proliferation-inducing substances to induce regrowth of myocardium. Current screening …
proliferation-inducing substances to induce regrowth of myocardium. Current screening …
PPARβ/δ: linking metabolism to regeneration
In contrast to the general belief that regeneration is a rare event, mainly occurring in simple
organisms, the ability of regeneration is widely distributed in the animal kingdom. Yet, the …
organisms, the ability of regeneration is widely distributed in the animal kingdom. Yet, the …
The role of metabolism in heart failure and regeneration
Heart failure is the leading cause of death worldwide. The inability of the adult mammalian
heart to regenerate following injury results in the development of systolic heart failure. Thus …
heart to regenerate following injury results in the development of systolic heart failure. Thus …