The initiation of eukaryotic DNA replication
A Costa, JFX Diffley - Annual review of biochemistry, 2022 - annualreviews.org
DNA replication in eukaryotic cells initiates from large numbers of sites called replication
origins. Initiation of replication from these origins must be tightly controlled to ensure the …
origins. Initiation of replication from these origins must be tightly controlled to ensure the …
PCNA loaders and unloaders—One ring that rules them all
During each cell duplication, the entirety of the genomic DNA in every cell must be
accurately and quickly copied. Given the short time available for the chore, the requirement …
accurately and quickly copied. Given the short time available for the chore, the requirement …
How Pol α-primase is targeted to replisomes to prime eukaryotic DNA replication
During eukaryotic DNA replication, Pol α-primase generates primers at replication origins to
start leading-strand synthesis and every few hundred nucleotides during discontinuous …
start leading-strand synthesis and every few hundred nucleotides during discontinuous …
Fast and efficient DNA replication with purified human proteins
Chromosome replication is performed by a complex and intricate ensemble of proteins
termed the replisome, where the DNA polymerases Polδ and Polε, DNA polymerase α …
termed the replisome, where the DNA polymerases Polδ and Polε, DNA polymerase α …
Structure of a human replisome shows the organisation and interactions of a DNA replication machine
ML Jones, Y Baris, MRG Taylor, JTP Yeeles - The EMBO journal, 2021 - embopress.org
The human replisome is an elaborate arrangement of molecular machines responsible for
accurate chromosome replication. At its heart is the CDC45‐MCM‐GINS (CMG) helicase …
accurate chromosome replication. At its heart is the CDC45‐MCM‐GINS (CMG) helicase …
Cryo-EM structure of the fork protection complex bound to CMG at a replication fork
The eukaryotic replisome, organized around the Cdc45-MCM-GINS (CMG) helicase,
orchestrates chromosome replication. Multiple factors associate directly with CMG, including …
orchestrates chromosome replication. Multiple factors associate directly with CMG, including …
Synergism between CMG helicase and leading strand DNA polymerase at replication fork
The replisome that replicates the eukaryotic genome consists of at least three engines: the
Cdc45-MCM-GINS (CMG) helicase that separates duplex DNA at the replication fork and …
Cdc45-MCM-GINS (CMG) helicase that separates duplex DNA at the replication fork and …
Single-molecule mapping of replisome progression
C Claussin, J Vazquez, I Whitehouse - Molecular cell, 2022 - cell.com
Fundamental aspects of DNA replication, such as the anatomy of replication stall sites, how
replisomes are influenced by gene transcription, and whether the progression of sister …
replisomes are influenced by gene transcription, and whether the progression of sister …
CryoEM structures of human CMG–ATPγS–DNA and CMG–AND-1 complexes
NJ Rzechorzek, SW Hardwick… - Nucleic acids …, 2020 - academic.oup.com
DNA unwinding in eukaryotic replication is performed by the Cdc45–MCM–GINS (CMG)
helicase. Although the CMG architecture has been elucidated, its mechanism of DNA …
helicase. Although the CMG architecture has been elucidated, its mechanism of DNA …
Structural mechanisms for replicating DNA in eukaryotes
I Attali, MR Botchan, JM Berger - Annual review of biochemistry, 2021 - annualreviews.org
The faithful and timely copying of DNA by molecular machines known as replisomes
depends on a disparate suite of enzymes and scaffolding factors working together in a …
depends on a disparate suite of enzymes and scaffolding factors working together in a …