Renal cell carcinoma (RCC) is characterized by an infrequent number of somatic mutations.
By contrast, epigenetic aberrations are commonly found in RCC, indicating that epigenetic …

Over the past few years, several genes, proteins and signalling pathways that are required
for embryogenesis have been shown to regulate tumour development and progression by …

Women with dense breasts have an increased lifetime risk of malignancy that has been
attributed to a higher epithelial density. Quantitative proteomics, collagen analysis, and …

The WAVE regulatory complex (WRC) controls actin cytoskeletal dynamics throughout the
cell by stimulating the actin-nucleating activity of the Arp2/3 complex at distinct membrane …

MicroRNAs play key roles in tumor metastasis. Here, we describe the regulation and
function of miR-218 in gastric cancer (GC) metastasis. miR-218 expression is decreased …

The importance of epigenetic modifications such as DNA methylation in tumorigenesis is
increasingly being appreciated. To define the genome‐wide pattern of DNA methylation in …

Dyslexia, or specific reading disability, is the most common learning disorder with a
complex, partially genetic basis, but its biochemical mechanisms remain poorly understood …

Loss of heterozygosity (LOH) involving several chromosome 3p regions accompanied by
chromosome 3p deletions are detected in almost 100% of small (SCLCs) and more than …

Netrin-1 and its receptors DCC (deleted in colorectal cancer) and the UNC5 orthologues
(human UNC5A–D and rodent UNC5H1–4) define a new mechanism for both the positive …

Promoter region hyermethylation and transcriptional silencing is a frequent cause of tumour
suppressor gene (TSG) inactivation in many types of human cancers. Functional epigenetic …