Manipulation of dendritic cell function by viruses

AL Cunningham, H Donaghy, AN Harman… - Current opinion in …, 2010 - Elsevier
Viruses manipulate the function of dendritic cells (DCs) to enhance their entry, spread,
survival and transmission. This review summarises recently published work identifying how …

Herpes simplex virus evasion of early host antiviral responses

EI Tognarelli, TF Palomino, N Corrales… - Frontiers in cellular …, 2019 - frontiersin.org
Herpes simplex viruses type 1 (HSV-1) and type 2 (HSV-2) have co-evolved with humans for
thousands of years and are present at a high prevalence in the population worldwide. HSV …

Herpes Simplex Virus 1 γ134.5 Protein Inhibits STING Activation That Restricts Viral Replication

S Pan, X Liu, Y Ma, Y Cao, B He - Journal of virology, 2018 - Am Soc Microbiol
The γ134. 5 gene of herpes simplex virus 1 (HSV-1) encodes a virulence factor that
promotes viral pathogenesis. Although it perturbs TANK-binding kinase 1 (TBK1) in the …

Recognition of herpes simplex viruses: toll-like receptors and beyond

Y Ma, B He - Journal of molecular biology, 2014 - Elsevier
Herpes simplex viruses (HSVs) are human pathogens that establish lytic and latent
infections. Reactivation from latency occurs intermittently, which represents a lifelong source …

Cytokines and chemokines: The vital role they play in herpes simplex virus mucosal immunology

JB Smith, JJ Herbert, NR Truong… - Frontiers in …, 2022 - frontiersin.org
Herpes simplex viruses (HSV) types 1 and 2 are ubiquitous infections in humans. They
cause orofacial and genital herpes with occasional severe complications. HSV2 also …

Inflammation and viral infection as disease modifiers in schizophrenia

HC Klein, PC Guest, H Dobrowolny, J Steiner - Frontiers in Psychiatry, 2023 - frontiersin.org
Numerous studies have now implicated a role for inflammation in schizophrenia. However,
many aspects surrounding this aspect of the disease are still controversial. This controversy …

Herpes simplex virus γ34. 5 interferes with autophagosome maturation and antigen presentation in dendritic cells

PAM Gobeil, DA Leib - MBio, 2012 - Am Soc Microbiol
The cellular autophagy response induced by herpes simplex virus 1 (HSV-1) is countered by
the viral γ34. 5 protein. γ34. 5 modulates autophagy by binding to the host autophagy …

Critical role of regulatory T cells in the latency and stress-induced reactivation of HSV-1

W Yu, S Geng, Y Suo, X Wei, Q Cai, B Wu, X Zhou… - Cell reports, 2018 - cell.com
Summary Herpes simplex virus 1 (HSV-1) spreads in populations through a latency entry
and reactivation cycle. The role of host immune-suppressive factor regulatory T cells (Treg …

Herpes Simplex Virus 1 Induces Phosphorylation and Reorganization of Lamin A/C through the γ134.5 Protein That Facilitates Nuclear Egress

S Wu, S Pan, L Zhang, J Baines, R Roller… - Journal of …, 2016 - Am Soc Microbiol
ABSTRACT Herpes simplex virus 1 (HSV-1) remodels nuclear membranes during virus
egress. Although the UL31 and UL34 proteins control nucleocapsid transit in infected cells …

p32 is a novel target for viral protein ICP34. 5 of herpes simplex virus type 1 and facilitates viral nuclear egress

Y Wang, Y Yang, S Wu, S Pan, C Zhou, Y Ma… - Journal of Biological …, 2014 - ASBMB
As a large double-stranded DNA virus, herpes simplex virus type 1 (HSV-1) assembles
capsids in the nucleus where the viral particles exit by budding through the inner nuclear …