Epstein–Barr virus latent genes

MS Kang, E Kieff - Experimental & molecular medicine, 2015 - nature.com
Abstract Latent Epstein–Barr virus (EBV) infection has a substantial role in causing many
human disorders. The persistence of these viral genomes in all malignant cells, yet with the …

Targeting persistent human papillomavirus infection

S Shanmugasundaram, J You - Viruses, 2017 - mdpi.com
While the majority of Human papillomavirus (HPV) infections are transient and cleared
within a couple of years following exposure, 10–20% of infections persist latently, leading to …

[HTML][HTML] Interaction of the bovine papillomavirus E2 protein with Brd4 tethers the viral DNA to host mitotic chromosomes

J You, JL Croyle, A Nishimura, K Ozato, PM Howley - Cell, 2004 - cell.com
The papillomavirus E2 protein tethers viral genomes to host mitotic chromosomes to ensure
genome maintenance. We have identified the bromodomain protein Brd4 as a major cellular …

Protein profiling with Epstein-Barr nuclear antigen-1 reveals an interaction with the herpesvirus-associated ubiquitin-specific protease HAUSP/USP7

MN Holowaty, M Zeghouf, H Wu, J Tellam… - Journal of Biological …, 2003 - ASBMB
The Epstein-Barr nuclear antigen-1 (EBNA1) protein of Epstein-Barr virus is important for the
replication, segregation, and transcriptional activation of latent Epstein-Barr virus genomes; …

Cancers associated with human gammaherpesviruses

KW Wen, L Wang, JR Menke, B Damania - The FEBS journal, 2022 - Wiley Online Library
Epstein–Barr virus (EBV; human herpesvirus 4; HHV‐4) and Kaposi sarcoma‐associated
herpesvirus (KSHV; human herpesvirus 8; HHV‐8) are human gammaherpesviruses that …

Kaposi's Sarcoma-Associated Herpesvirus Latency-Associated Nuclear Antigen 1 Mediates Episome Persistence through cis-Acting Terminal Repeat (TR) Sequence …

ME Ballestas, KM Kaye - Journal of virology, 2001 - Am Soc Microbiol
ABSTRACT Kaposi's sarcoma (KS)-associated herpesvirus (KSHV)(also known as human
herpesvirus 8) latently infects KS tumors, primary effusion lymphomas (PELs), and PEL cell …

Episomal vectors for gene expression in mammalian cells

K Van Craenenbroeck, P Vanhoenacker… - European journal of …, 2000 - Wiley Online Library
An important reason for preferring mammalian cells for heterologous gene expression is
their ability to make authentic proteins containing post‐translational modifications similar to …

The EBV nuclear antigen 1 (EBNA1) enhances B cell immortalization several thousandfold

S Humme, G Reisbach, R Feederle… - Proceedings of the …, 2003 - National Acad Sciences
The Epstein–Barr virus (EBV) nuclear antigen 1 (EBNA1) is one of the earliest viral proteins
expressed after infection and is the only latent protein consistently expressed in viral …

EBNA‐1: a protein pivotal to latent infection by Epstein–Barr virus

ER Leight, B Sugden - Reviews in medical virology, 2000 - Wiley Online Library
Epstein–Barr nuclear antigen 1, or EBNA‐1, is required for the replication of the EBV
genome as an extra‒chromosomal element and is a key transcriptional regulator of this …

Keeping it quiet: chromatin control of gammaherpesvirus latency

PM Lieberman - Nature reviews Microbiology, 2013 - nature.com
Abstract The human gammaherpesviruses Epstein–Barr virus (EBV) and Kaposi's sarcoma-
associated herpesvirus (KSHV) establish long-term latent infections associated with diverse …