Ferroptosis is a form of regulated cell death that is characterized by iron-dependent
oxidative damage and subsequent plasma membrane ruptures and the release of damage …

A growing subset of metalloenzymes activates dioxygen with nonheme diiron active sites to
effect substrate oxidations that range from the hydroxylation of methane and the …

In recent years, significant progress has been made in understanding the geometric and
electronic structures of the active sites of non-heme iron enzymes and the contributions of …

Protein Radicals in Enzyme Catalysis. [Chem. Rev. 1998, 98, 705−762 | Chemical Reviews ACS
ACS Publications C&EN CAS Find my institution Log In Chemical Reviews ACS Publications …

▪ Abstract Desaturation of a fatty acid first involves the enzymatic removal of a hydrogen from
a methylene group in an acyl chain, a highly energy-demanding step that requires an …

Dioxygen activation by metalloenzymes generally proceeds through one of two
fundamentally different routes. Some enzymes, such as the ferric ion containing intradiol …

Ribonucleotide reductases (RNRs) catalyze the conversion of nucleotides to
deoxynucleotides in all organisms (eq 1). 1-3 These enzymes play an essential role in DNA …

1. History 3422. Activation barriers 3432.1 Redox potentials 3442.2 Reorganization energy
3443. Electronic coupling 3454. Ru-modified proteins 3484.1 Reorganization energy …

Metalloenzymes effect a variety of important chemical transformations, often involving small
molecule substrates or products such as molecular oxygen, hydrogen, nitrogen, and water …

Ribonucleotide reductase (RNR) is the enzyme responsible for the conversion of
ribonucleotides to 2′-deoxyribonucleotides and thereby provides the precursors needed …