Immunoporosis: role of innate immune cells in osteoporosis
Osteoporosis or porous bone disorder is the result of an imbalance in an otherwise highly
balanced physiological process known as 'bone remodeling'. The immune system is …
balanced physiological process known as 'bone remodeling'. The immune system is …
Eosinophil knockout humans: uncovering the role of eosinophils through eosinophil-directed biological therapies
The enigmatic eosinophil has emerged as an exciting component of the immune system,
involved in a plethora of homeostatic and inflammatory responses. Substantial progress has …
involved in a plethora of homeostatic and inflammatory responses. Substantial progress has …
Single-cell transcriptomics analysis of bullous pemphigoid unveils immune-stromal crosstalk in type 2 inflammatory disease
T Liu, Z Wang, X Xue, Z Wang, Y Zhang, Z Mi… - Nature …, 2024 - nature.com
Bullous pemphigoid (BP) is a type 2 inflammation-and immunity-driven skin disease, yet a
comprehensive understanding of the immune landscape, particularly immune-stromal …
comprehensive understanding of the immune landscape, particularly immune-stromal …
Bullous pemphigoid: trigger and predisposing factors
Bullous pemphigoid (BP) is the most frequent autoimmune subepidermal blistering disease
provoked by autoantibodies directed against two hemidesmosomal proteins: BP180 and …
provoked by autoantibodies directed against two hemidesmosomal proteins: BP180 and …
Tyrosine kinases in autoimmune and inflammatory skin diseases
Tyrosine kinases relay signals from diverse leukocyte antigen receptors, innate immune
receptors, and cytokine receptors, and therefore mediate the recruitment and activation of …
receptors, and cytokine receptors, and therefore mediate the recruitment and activation of …
New insights into the pathogenesis of bullous pemphigoid: 2019 update
G Genovese, G Di Zenzo, E Cozzani, E Berti… - Frontiers in …, 2019 - frontiersin.org
There are several lines of evidence indicating that the physiopathological bases of bullous
pemphigoid (BP), the most common subepidermal autoimmune bullous disease, are …
pemphigoid (BP), the most common subepidermal autoimmune bullous disease, are …
Dermatitis herpetiformis: novel perspectives
E Antiga, R Maglie, L Quintarelli, A Verdelli… - Frontiers in …, 2019 - frontiersin.org
Dermatitis herpetiformis (DH) is an inflammatory disease of the skin, considered the specific
cutaneous manifestation of celiac disease (CD). Both DH and CD occur in gluten-sensitive …
cutaneous manifestation of celiac disease (CD). Both DH and CD occur in gluten-sensitive …
NF-κB perturbation reveals unique immunomodulatory functions in Prx1+ fibroblasts that promote development of atopic dermatitis
Skin is composed of diverse cell populations that cooperatively maintain homeostasis. Up-
regulation of the nuclear factor κB (NF-κB) pathway may lead to the development of chronic …
regulation of the nuclear factor κB (NF-κB) pathway may lead to the development of chronic …
Pathophysiologic mechanisms of itch in bullous pemphigoid
T Hashimoto, CD Kursewicz, RA Fayne… - Journal of the American …, 2020 - Elsevier
Background One of the hallmarks of bullous pemphigoid (BP) is moderate to severe chronic
itch. Managing this is difficult because little is known about the mechanisms of itch in BP …
itch. Managing this is difficult because little is known about the mechanisms of itch in BP …
Serum and blister fluid levels of cytokines and chemokines in pemphigus and bullous pemphigoid
Bullous pemphigoid and pemphigus constitute two major autoimmune blistering diseases
(AIBD) with complicated disease pathomechanisms involving a multitude of cytokines and …
(AIBD) with complicated disease pathomechanisms involving a multitude of cytokines and …