Hypertension meets osteoarthritis—revisiting the vascular aetiology hypothesis

K Ching, X Houard, F Berenbaum, C Wen - Nature Reviews …, 2021 - nature.com
Osteoarthritis (OA) is a whole-joint disease characterized by subchondral bone perfusion
abnormalities and neovascular invasion into the synovium and articular cartilage. In addition …

[HTML][HTML] Exocytosis of Weibel–Palade bodies: how to unpack a vascular emergency kit

M Schillemans, E Karampini, M Kat… - Journal of Thrombosis and …, 2019 - Elsevier
The blood vessel wall has a number of self‐healing properties, enabling it to minimize blood
loss and prevent or overcome infections in the event of vascular trauma. Endothelial cells …

Weibel Palade bodies: unique secretory organelles of endothelial cells that control blood vessel homeostasis

J Naß, J Terglane, V Gerke - Frontiers in Cell and Developmental …, 2021 - frontiersin.org
Vascular endothelial cells produce and release compounds regulating vascular tone, blood
vessel growth and differentiation, plasma composition, coagulation and fibrinolysis, and also …

Inflammatory, regulatory, and autophagy co-expression modules and hub genes underlie the peripheral immune response to human intracerebral hemorrhage

M Durocher, BP Ander, G Jickling, F Hamade… - Journal of …, 2019 - Springer
Background Intracerebral hemorrhage (ICH) has a high morbidity and mortality. The
peripheral immune system and cross-talk between peripheral blood and brain have been …

GDP/GTP exchange factor MADD drives activation and recruitment of secretory Rab GTPases to Weibel-Palade bodies

M Kat, PE Bürgisser, H Janssen, IM De Cuyper… - Blood …, 2021 - ashpublications.org
Abstract von Willebrand factor (VWF) is an essential hemostatic protein that is synthesized
and secreted by endothelial cells and stored in Weibel-Palade bodies (WPBs). The …

A defined clathrin-mediated trafficking pathway regulates sFLT1/VEGFR1 secretion from endothelial cells

K Kinghorn, A Gill, A Marvin, R Li, K Quigley, S Singh… - Angiogenesis, 2024 - Springer
Abstract FLT1/VEGFR1 negatively regulates VEGF-A signaling and is required for proper
vessel morphogenesis during vascular development and vessel homeostasis. Although a …

Recent insights into the regulation of coagulation and thrombosis

X Li, MMS Sim, JP Wood - Arteriosclerosis, thrombosis, and …, 2020 - Am Heart Assoc
Although procoagulant TF is clearly expressed in the vascular subendothelium, it has also
been proposed that many different cell types express an inactive, encrypted form of TF that …

[HTML][HTML] Defective AP-3-dependent VAMP8 trafficking impairs Weibel-Palade body exocytosis in Hermansky-Pudlak Syndrome type 2 blood outgrowth endothelial …

E Karampini, M Schillemans, M Hofman… - …, 2019 - ncbi.nlm.nih.gov
Weibel-Palade bodies are endothelial secretory organelles that contain von Willebrand
factor, P-selectin and CD63. Release of von Willebrand factor from Weibel-Palade bodies is …

A new look at an old body: molecular determinants of Weibel-Palade body composition and VWF exocytosis

S Hordijk, T Carter, R Bierings - Journal of Thrombosis and Haemostasis, 2024 - Elsevier
Endothelial cells, forming a monolayer along blood vessels, intricately regulate vascular
hemostasis, inflammatory responses, and angiogenesis. A key determinant of these …

Complement promotes endothelial von Willebrand factor and angiopoietin-2 release in obstructive sleep apnea

S Gao, M Emin, T Thoma, K Pastellas, F Castagna… - Sleep, 2021 - academic.oup.com
Abstract Study Objective Obstructive sleep apnea (OSA) is highly prevalent and triples
vascular thromboembolic risk. Intermittent hypoxia (IH) during transient cessation of …