Single agent checkpoint inhibitor therapy has not been effective for most gastrointestinal
solid tumors, but combination therapy with drugs targeting additional immunosuppressive …

Chemokines are critical mediators of cell migration during routine immune surveillance,
inflammation, and development. Chemokines bind to G protein–coupled receptors and …

Chemokine receptors are critical regulators of cell migration in the context of immune
surveillance, inflammation, and development. The G protein–coupled chemokine receptor …

The chemokine receptor CXCR4 belongs to the large superfamily of G protein-coupled
receptors, and is directly involved in a number of biological processes including …

Chemokines are the largest family of cytokines in human immunophysiology. These proteins
are defined by four invariant cysteines and are categorized based on the sequence around …

ABSTRACT T-20 is a synthetic peptide that potently inhibits replication of human
immunodeficiency virus type 1 by interfering with the transition of the transmembrane …

CCR5 and CXCR4 are the major HIV-1 coreceptors for R5 and X4 HIV-1 strains,
respectively, and a threshold number of CD4 and chemokine receptor molecules is required …

Stem cell homing and breast cancer metastasis are orchestrated by the chemokine stromal
cell–derived factor 1 (SDF-1) and its receptor CXCR4. Here, we report the nuclear magnetic …

Infection of target cells by HIV is a complex, multi-stage process involving attachment to host
cells and CD4 binding, coreceptor binding, and membrane fusion. Drugs that block HIV …

Background The formation of the posterior lateral line of teleosts depends on the migration
of a primordium that originates near the otic vesicle and moves to the tip of the tail. Groups of …