Pathogenicity and Virulence of Legionella: Intracellular replication and host response

D Chauhan, SR Shames - Virulence, 2021 - Taylor & Francis
Bacteria of the genus Legionella are natural pathogens of amoebae that can cause a severe
pneumonia in humans called Legionnaires' Disease. Human disease results from inhalation …

Concept about the Virulence Factor of Legionella

JL Yang, D Li, XY Zhan - Microorganisms, 2022 - mdpi.com
Pathogenic species of Legionella can infect human alveolar macrophages through
Legionella-containing aerosols to cause a disease called Legionellosis, which has two …

Protein sociology of ProA, Mip and other secreted virulence factors at the Legionella pneumophila surface

L Scheithauer, MS Karagöz, BE Mayer… - Frontiers in Cellular and …, 2023 - frontiersin.org
The pathogenicity of L. pneumophila, the causative agent of Legionnaires' disease, depends
on an arsenal of interacting proteins. Here we describe how surface-associated and …

Molecular regulation of virulence in Legionella pneumophila

CI Graham, TL MacMartin, TR de Kievit… - Molecular …, 2024 - Wiley Online Library
Legionella pneumophila is a gram‐negative bacteria found in natural and anthropogenic
aquatic environments such as evaporative cooling towers, where it reproduces as an …

The Legionella collagen-like protein employs a distinct binding mechanism for the recognition of host glycosaminoglycans

S Rehman, AK Antonovic, IE McIntire, H Zheng… - Nature …, 2024 - nature.com
Bacterial adhesion is a fundamental process which enables colonisation of niche
environments and is key for infection. However, in Legionella pneumophila, the causative …

The Role of Lipids in Legionella-Host Interaction

B Kowalczyk, E Chmiel… - International Journal of …, 2021 - mdpi.com
Legionella are Gram-stain-negative rods associated with water environments: either natural
or man-made systems. The inhalation of aerosols containing Legionella bacteria leads to …

The unity of opposites: Strategic interplay between bacterial effectors to regulate cellular homeostasis

S Iyer, C Das - Journal of Biological Chemistry, 2021 - ASBMB
Legionella pneumophila is a facultative intracellular pathogen that uses the Dot/Icm Type IV
secretion system (T4SS) to translocate many effectors into its host and establish a safe …

Legionella pneumophila—Virulence Factors and the Possibility of Infection in Dental Practice

J Talapko, E Frauenheim, M Juzbašić, M Tomas… - Microorganisms, 2022 - mdpi.com
Legionella pneumophila is defined as a bacterium that can cause severe pneumonia. It is
found in the natural environment and in water, and is often found in water tanks. It can be an …

The type II secretion system as an underappreciated and understudied mediator of interbacterial antagonism

NP Cianciotto - Infection and Immunity, 2024 - journals.asm.org
Interbacterial antagonism involves all major phyla, occurs across the full range of ecological
niches, and has great significance for the environment, clinical arena, and agricultural and …

TSE-ARF: An adaptive prediction method of effectors across secretion system types

X Tang, L Luo, S Wang - Analytical Biochemistry, 2024 - Elsevier
Bacterial effector proteins are secreted by a variety of protein secretion systems and play an
important role in the interaction between the host and pathogenic bacteria. Therefore, it is …