Ischemic cardiomyopathy (ICM) is a special type of coronary heart disease or an advanced
stage of the disease, which is related to the pathological mechanism of primary dilated …

Autophagy, one of the arms of proteostasis, influences aging and age-related diseases.
Recently, the discovery of additional roles of autophagy-related proteins in non-canonical …

Atg7 is an indispensable factor that plays a role in canonical nonselective autophagy. Here
we show that genetic ablation of Atg7 in outer hair cells (OHCs) in mice caused stereocilium …

Matrine is a natural alkaloid isolated from the root and stem of the legume plant Sophora. Its
anti-proliferative and pro-apoptotic effects on several types of cancer have been well …

Abstract Mitochondrial Rho GTPase 1 (Miro1) protein is a well-known adaptor for
mitochondrial transport and also regulates mitochondrial quality control and function …

Mitochondrial dysfunction is a major contributor to myocyte loss and the development of
heart failure. Myocytes have quality control mechanisms to retain functional mitochondria by …

Cardiovascular disease (CVD) leads to high morbidity and mortality rates worldwide.
Accumulating evidence has revealed that mitochondria dysfunction is implicated in CVD …

Over the past decade, autophagy has emerged as a critical regulatory mechanism of the
immune system through critically controlling various aspects of T cell biology and …

Cardiovascular diseases are one of the leading causes of death and global health problems
worldwide, and ischemic heart disease is the most common cause of heart failure (HF). The …

Heart failure is defined as a drop in heart's pump function, accounting for reduced blood
output and venous stasis, and constitutes the end stage of various cardiovascular diseases …