Objective: To review the present status of bioartificial liver (BAL) devices and their obtained
clinical results. Background: Acute liver failure (ALF) is a disease with a high mortality …

Liver is a central nexus integrating metabolic and immunologic homeostasis in the human
body, and the direct or indirect target of most molecular therapeutics. A wide spectrum of …

This article describes the development history of packed-bed bioreactors (PBRs) used for
the culture of mammalian cells. It further reviews the current applications of PBRs and …

We developed 2 types of hybrid artificial liver modules using hepatocyte organoid culture.
One was a polyurethane foam (PUF)/hepatocyte spheroid packed‐bed module. Hepatocytes …

Purpose To determine whether the centric reordered snapshot fast low‐angle shot
(reordered turboFLASH) magnetic resonance (MR) images with no, low, and high motion …

Insufficient donor organs for orthotopic liver transplantation worldwide have urgently
increased the requirement for new therapies for acute and chronic liver disease. Whilst none …

Aim of the study was to evaluate treatment efficacy and safety of a scaled-up version of our
porcine hepatocytes based BAL system in pigs with complete liver ischemia (LIS). Thirty-one …

Several attempts have been made to develop bioartificial support for the treatment of
patients with acute or fulminant liver failure. In this paper, the authors have reviewed the …

In this second part of our systematic review on the research area of 3D cell culture in micro-
bioreactors we give a detailed description of the published work with regard to the existing …

The development of a fulminant hepatic failure (FHF) model is necessary for evaluating the
efficacy of extracorporeal liver support systems. Recognizing the multifaceted functions of …