Peroxisomes carry out various oxidative reactions that are tightly regulated to adapt to the
changing needs of the cell and varying external environments. Accordingly, they are …

In mammals, peroxisomes perform crucial functions in cellular metabolism, signalling and
viral defense which are essential to the health and viability of the organism. In order to …

The cellular ability to react to environmental fluctuations depends on signaling networks that
are controlled by the dynamic activities of kinases and phosphatases. Here, to gain insight …

A crucial component of the analysis of shotgun proteomics datasets is the search engine, an
algorithm that attempts to identify the peptide sequence from the parent molecular ion that …

Peroxisomes contribute to several crucial metabolic processes such as β-oxidation of fatty
acids, biosynthesis of ether phospholipids and metabolism of reactive oxygen species …

Exchange of macromolecules between the nucleus and cytoplasm is a key regulatory event
in the expression of a cell's genome. This exchange requires a dedicated transport …

The increased life expectancy and the expansion of the elderly population are stimulating
research into aging. Aging may be viewed as a multifactorial process that results from the …

The ability of cells and organisms to survive and function through changes in temperature
evolved from their specific adaptations to nonoptimal growth conditions. Responses to …

Dissecting and studying cellular systems requires the ability to specifically isolate distinct
proteins along with the co-assembled constituents of their associated complexes. Affinity …

Yeast Pah1p is the phosphatidate phosphatase that catalyzes the penultimate step in
triacylglycerol synthesis and plays a role in the transcriptional regulation of phospholipid …