Efficient and regulated nucleocytoplasmic trafficking of macromolecules to the correct
subcellular compartment is critical for proper functions of the eukaryotic cell. The majority of …

Arginine methylation is a common post-translational modification functioning as an
epigenetic regulator of transcription and playing key roles in pre-mRNA splicing, DNA …

Cytoplasmic FUS aggregates are a pathological hallmark in a subset of patients with
frontotemporal dementia (FTD) or amyotrophic lateral sclerosis (ALS). A key step that is …

Ribonucleoprotein (RNP) granules are membrane-less organelles consisting of RNA-
binding proteins (RBPs) and RNA. RNA granules form through liquid–liquid phase …

We have made rapid progress in recent years in identifying the genetic causes of many
human diseases. However, despite this recent progress, our mechanistic understanding of …

Cerebrospinal fluid analyses and neuroimaging can identify the underlying pathophysiology
at the earliest stage of some neurodegenerative disorders, but do not have the scalability …

RNA binding proteins are critical to the maintenance of the transcriptome via controlled
regulation of RNA processing and transport. Alterations of these proteins impact multiple …

Nuclear import receptors, also called importins, mediate nuclear import of proteins and
chaperone aggregation-prone cargoes (eg, neurodegeneration-linked RNA-binding …

Misfolded or mislocalized RNA‐binding proteins (RBP s) and, consequently, altered mRNA
processing, can cause neuronal dysfunction, eventually leading to neurodegeneration. Two …

Arginine methylation is a ubiquitous post-translational modification. Three predominant
types of arginine-guanidino methylation occur in Eukarya: mono (Rme1/MMA), symmetric …