The peroxisome proliferator-activated receptor (PPAR) family includes three transcription
factors: PPARα, PPARβ/δ, and PPARγ. PPAR are nuclear receptors activated by oxidised …

Iron is a transition metal that due to its inherent ability to exchange electrons with a variety of
molecules is essential to support life. In mammals, iron exists mostly in the form of heme …

Essential oils are complex mixtures isolated from aromatic plants which may possess
antioxidant and anti-inflammatory activities of interest in thye food and cosmetic industries as …

Inflammation is a protective response that develops against tissue injury and infection.
Chronic inflammation, on the other hand, is the key player in the pathogenesis of many …

Angiotensin II receptor blockers (ARBs, collectively called sartans) are widely used
compounds therapeutically effective in cardiovascular disorders, renal disease, the …

Cyclooxygenase-2 (COX-2), the rate-limiting enzyme in prostaglandin biosynthesis, plays a
key role in inflammation and circulatory homeostasis. Peroxisome proliferator-activated …

The cyclooxygenase (COX, prostaglandin endoperoxide synthase) is a key enzyme in
prostaglandin biosynthesis. Two isoforms of COX, COX-1 and COX-2, have been identified …

Fatty acid-binding proteins are cytosolic fatty acid chaperones, and the adipocyte isoform,
aP2, plays an important role in obesity and glucose metabolism. Recently, this protein has …

Objectives: To provide an overview on: 1) the expression of cyclooxygenase (COX)-2 in
articular tissues; 2) the role of prostaglandin E2 (PGE2) in these tissue functions; and 3) …

Prostanoids represent a group of lipid mediators that are produced from arachidonic acid via
the cyclooxygenase pathway. Once formed, the prostanoids are released from the cells and …