Background White matter hyperintensities of presumed vascular origin (WMH) are one of the
imaging features of cerebral small vessel disease. Controversies persist about the effects of …

White matter hyperintensities (WMHs) are frequently seen on brain magnetic resonance
imaging scans of older people. Usually interpreted clinically as a surrogate for cerebral …

Recent research on bilirubin, a historically well-known waste product of heme catabolism,
suggests an entirely new function as a metabolic hormone that drives gene transcription by …

A systematic review was conducted to identify risk factors associated with the onset and
progression of Alzheimer's disease (AD). Moderate and high quality systematic reviews …

Studies have shown differences in specific cognitive ability domains and risk of Alzheimer's
disease between the men and women at later age. However it is important to know that sex …

Background and Purpose—Arterial stiffening reduces damping of the arterial waveform and
hence increases pulsatility of cerebral blood flow, potentially damaging small vessels. In the …

Over the last 20 years, evidence about the clinical correlates of cerebral white matter
changes (WMC; also called leukoaraiosis) has been accumulating. WMC are now listed …

Background and Purpose—Cerebral amyloid angiopathy (CAA) is a degenerative disorder
characterized by amyloid-β (Aβ) deposition in the blood–brain barrier (BBB). CAA …

Background Type 2 diabetes may increase the risk of amnestic mild cognitive impairment
(aMCI) through Alzheimer's disease (AD)-related and vascular pathology and may also …

Exercise is commonly prescribed as a lifestyle treatment for chronic metabolic diseases as it
functions as an insulin sensitizer, cardio-protectant, and essential lifestyle tool for effective …