The integrity of the genome is under constant threat of environmental and endogenous
agents that cause DNA damage. Endogenous damage is particularly pervasive, occurring at …

Twenty years after landmark publications, there is a consensus that the somatic
hypermutation (SHM) status of the clonotypic immunoglobulin heavy variable (IGHV) gene is …

Chronic Lymphocytic Leukemia (CLL) represents the most common leukemia in the western
world and remains incurable. Leukemic cells organize and interact in the lymphoid tissues …

Background Ion channels are emerging as promising oncological targets. The potassium
channels Kv1. 3 and IKCa are highly expressed in the plasma membrane and mitochondria …

Germinal centers (GCs) play a central role in generating an effective immune response
against infectious pathogens, and failures in their regulating mechanisms can lead to the …

Chronic lymphocytic leukaemia (CLL) is a malignancy of clonally expanded antigen-
switched, neoplastic, mature B cells. CLL is characterised by a variable degree of …

Introduction Medicine stands at the threshold of a new era heralded by the vast potential of
cell engineering. Like advances made possible by genetic engineering, current prospects …

The term monoclonal B-cell lymphocytosis (MBL) describes the presence of a clonal B cell
population with a count of less than 5× 109/L and no symptoms or signs of disease. Based …

Simple Summary In this study, we present a retrospective analysis of a large cohort of CLL
patients with a particular focus on those with a borderline immunoglobulin heavy variable …

A defining feature of the immune system concerns the generation of a remarkably diverse
repertoire of antigen-specific lymphocytes, each carrying a unique antigen receptor: the …