Parathyroid hormone-related protein (PTHrP) was discovered as a result of a search for the
circulating factor secreted by cancers which causes the common paraneoplastic syndrome …

The kidneys play a vital role in mineral homeostasis. In this review, the handling of calcium
and the methods currently applied to measuring its intracellular concentration are discussed …

Sodium (Na+) is the principal osmole in extracellular fluid; as such, the total body content of
Na+ and Cl-, its primary anion, determine the extracellular fluid volume. Renal excretion or …

A RIA for PTH-related protein (PTHrP) is described, using a polyclonal goat antiserum
against synthetic PTHrP-(l–40) and recombinant PTHrP-(l–84) as standard. The detection …

PTH-related protein (PTHrP) is homologous with PTH. PTH, an effective anabolic agent for
treating osteoporosis, has been shown to stimulate both bone resorption by osteoclasts and …

Parathyroid hormone-related protein (PTHrP) is a prohormone that is posttranslationally
processed to a family of mature secretory forms, each of which has its own cognate receptor …

Abstract Osteoblast activity and plasma 1, 25 (OH) 2vitamin D are increased in HPT but
suppressed in HHM. To model HPT and HHM, we directly compared multiday continuous …

PTH and PTH-related protein (PTHrP) cause primary hyperparathyroidism and humoral
hypercalcemia of malignancy (HHM), respectively. These syndromes are similar in several …

PTH-related protein (PTHrP) interacts, via its amino-terminal 34 residues, with PTH
receptors on osteoblasts to stimulate osteoclastic bone resorption indirectly. We now report …

We have recently shown that a carboxyl-terminal sequence of parathyroid hormone-related
protein, PTHrP [107–139], is a potent direct inhibitor of osteoclastic bone resorption. We now …