Chronic pain is a leading cause of disability globally and associated with enormous health-
care costs. The discrepancy between the extent of tissue damage and the magnitude of …

Immune-mediated inflammatory diseases are common and clinically diverse. Although they
are currently incurable, the therapeutic armamentarium for immune-mediated inflammatory …

As inflammation in the brain contributes to several neurological and psychiatric diseases,
the cause of neuroinflammation is being widely studied. The causes of neuroinflammation …

Despite nearly three decades of advances in the management of rheumatoid arthritis (RA), a
substantial minority of patients are exposed to multiple DMARDs without necessarily …

Fatigue is a complex phenomenon and an important health concern for many people with
chronic inflammatory rheumatic diseases, such as rheumatoid arthritis, psoriatic arthritis …

Patients with systemic lupus erythematosus (SLE) frequently show symptoms of central
nervous system (CNS) involvement, termed neuropsychiatric SLE (NPSLE). The CNS …

Psychiatric sequelae substantially contribute to the post-acute burden of disease associated
with COVID-19, persisting months after clearance of the virus. Brain imaging shows white …

Rheumatoid arthritis (RA) is a chronic inflammatory disease, affecting mostly women with a
female/male ratio of 3: 1. It is characterized by symmetrical polyarthritis, leading to …

Chronic pain affects more than 50 million Americans. Treatments remain inadequate, in
large part, because the pathophysiological mechanisms underlying the development of …

Background and Objectives To investigate chronic inflammation in relation to cognitive
aging by comparison of an epigenetic and serum biomarker of C-reactive protein and their …