Systemic sclerosis (SSc) is an idiopathic systemic autoimmune disease. It is characterized
by a triad of hallmarks: immune dysfunction, fibrosis and vasculopathy. Immune dysfunction …

Background The treatment of systemic sclerosis (SSc) represents a great clinical challenge
because of the complex disease pathogenesis including vascular, fibrotic, and immune T …

Unbiased genetic studies have uncovered surprising molecular mechanisms in human
cellular immunity and autoimmunity. We performed whole-exome sequencing and targeted …

Autoimmune neuroinflammatory diseases are a group of disorders resulting from abnormal
immune responses in the nervous system, causing inflammation and tissue damage. The …

Functional cytokine networks have been poorly characterized in systemic sclerosis (SSc).
While interleukin-17A (IL-17A) is increased in SSc skin and other organs, its role is still …

Systemic sclerosis (SSc) is a chronic systemic disease within the spectrum of connective
tissue diseases, specifically characterized by vascular abnormalities and inflammatory and …

Systemic sclerosis (SSc) is a rare autoimmune disease that is characterized by fibrosis,
inflammation, and vasculopathy of the skin and internal organs. The etiopathogenesis of …

Sarcoidosis, a multisystem granulomatous disorder, has historically been classified as Th1-
driven disease. However, increasing data demonstrate a key role of Th17-cell plasticity in …

In systemic sclerosis (SSc) immuno-inflammatory events are central to disease
development. Amongst other mediators of inflammation, interleukin 17 (IL-17) and Th17 …

Introduction Interstitial lung disease (ILD) is the leading cause of mortality in patients with
systemic sclerosis (SSc). Risk of developing progressive ILD is highest among patients with …