Regulation of microRNA biogenesis and its crosstalk with other cellular pathways

T Treiber, N Treiber, G Meister - Nature reviews Molecular cell biology, 2019 - nature.com
MicroRNAs (miRNAs) are short non-coding RNAs that inhibit the expression of target genes
by directly binding to their mRNAs. miRNAs are transcribed as precursor molecules, which …

RNA G-quadruplexes (rG4s): genomics and biological functions

K Lyu, EYC Chow, X Mou, TF Chan… - Nucleic acids …, 2021 - academic.oup.com
Abstract G-quadruplexes (G4s) are non-classical DNA or RNA secondary structures that
have been first observed decades ago. Over the years, these four-stranded structural motifs …

Properties and biological impact of RNA G-quadruplexes: from order to turmoil and back

P Kharel, G Becker, V Tsvetkov… - Nucleic acids research, 2020 - academic.oup.com
Abstract Guanine-quadruplexes (G4s) are non-canonical four-stranded structures that can
be formed in guanine (G) rich nucleic acid sequences. A great number of G-rich sequences …

A guide to computational methods for G-quadruplex prediction

E Puig Lombardi, A Londoño-Vallejo - Nucleic acids research, 2020 - academic.oup.com
Guanine-rich nucleic acids can fold into the non-B DNA or RNA structures called G-
quadruplexes (G4). Recent methodological developments have allowed the characterization …

[HTML][HTML] Innate immune suppression by SARS-CoV-2 mRNA vaccinations: The role of G-quadruplexes, exosomes, and MicroRNAs

S Seneff, G Nigh, AM Kyriakopoulos… - Food and Chemical …, 2022 - Elsevier
Abstract The mRNA SARS-CoV-2 vaccines were brought to market in response to the public
health crises of Covid-19. The utilization of mRNA vaccines in the context of infectious …

The diverse structural landscape of quadruplexes

HL Lightfoot, T Hagen, NJ Tatum, J Hall - FEBS letters, 2019 - Wiley Online Library
G‐quadruplexes are secondary structures formed in G‐rich sequences in DNA and RNA.
Considerable research over the past three decades has led to in‐depth insight into these …

Biological relevance and therapeutic potential of G-quadruplex structures in the human noncoding transcriptome

M Tassinari, SN Richter, P Gandellini - Nucleic Acids Research, 2021 - academic.oup.com
Noncoding RNAs are functional transcripts that are not translated into proteins. They
represent the largest portion of the human transcriptome and have been shown to regulate …

Developing novel G-quadruplex ligands: From interaction with nucleic acids to interfering with nucleic acid–protein interaction

ZY Sun, XN Wang, SQ Cheng, XX Su, TM Ou - Molecules, 2019 - mdpi.com
G-quadruplex is a special secondary structure of nucleic acids in guanine-rich sequences of
genome. G-quadruplexes have been proved to be involved in the regulation of replication …

The role of RNA G‐quadruplexes in human diseases and therapeutic strategies

P Kharel, S Balaratnam, N Beals… - Wiley Interdisciplinary …, 2020 - Wiley Online Library
G‐quadruplexes (GQs) are four‐stranded secondary structures formed by G‐rich nucleic
acid sequence (s). DNA GQs are present abundantly in the genome and affect a wide range …

Beyond small molecules: targeting G-quadruplex structures with oligonucleotides and their analogues

E Cadoni, L De Paepe, A Manicardi… - Nucleic Acids …, 2021 - academic.oup.com
Abstract G-Quadruplexes (G4s) are widely studied secondary DNA/RNA structures, naturally
occurring when G-rich sequences are present. The strategic localization of G4s in genome …