Reductive amination plays a paramount role in pharmaceutical and medicinal chemistry
owing to its synthetic merits and the ubiquitous presence of amines among biologically …

Background Recent US and UK clinical practice guidelines recommend that second‐
generation antidepressants should be considered amongst the best first‐line options when …

Objective: To assess the relative antidepressant efficacy of escitalopram and comparator
antidepressants. Research design and methods: A meta-analysis was performed using …

Summary Abstract Escitalopram (Cipralex®, Lexapro™), the active S-enantiomer of the
racemic selective serotonin reuptake inhibitor (SSRI) citalopram (RS-citalopram), is a highly …

Escitalopram (escitalopram oxalate; Cipralex®, Lexapro®) is a selective serotonin reuptake
inhibitor (SSRI) used for the treatment of major depressive disorder (MDD) and anxiety …

A pro-inflammatory state and a dysregulation in the tryptophan/kynurenine pathway have
been documented in depression. This study examined whether treatment with the SSRI …

Escitalopram (escitalopram oxalate; Cipralex®, Lexapro®), a selective serotonin reuptake
inhibitor (SSRI) indicated for the treatment of major depressive disorder (MDD) …

Background: The S-enantiomer of citalopram (escitalopram) is the active moiety linked to the
anti-depressant effects associated with citalopram (the racemate). For escitalopram to be …

The aim of this review was to assess the clinical relevance of the relative antidepressant
efficacy of escitalopram and citalopram by meta-analysis. Studies in major depressive …

Objective: Venlafaxine is a commonly prescribed antidepressant, but whether its
noradrenergic effects impart increased cardiovascular risk is unknown. We sought to …