TERT—regulation and roles in cancer formation

M Dratwa, B Wysoczańska, P Łacina, T Kubik… - Frontiers in …, 2020 - frontiersin.org
Telomerase reverse transcriptase (TERT) is a catalytic subunit of telomerase. Telomerase
complex plays a key role in cancer formation by telomere dependent or independent …

Absorption, metabolism, anti-cancer effect and molecular targets of epigallocatechin gallate (EGCG): An updated review

RY Gan, HB Li, ZQ Sui, H Corke - Critical reviews in food science …, 2018 - Taylor & Francis
Green tea is one of the most popular beverages in the world, especially in Asian countries.
Consumption of green tea has been demonstrated to possess many health benefits, which …

Polyphenols as potent epigenetics agents for cancer

P Rajendran, SA Abdelsalam, K Renu… - International journal of …, 2022 - mdpi.com
Human diseases such as cancer can be caused by aberrant epigenetic regulation.
Polyphenols play a major role in mammalian epigenome regulation through mechanisms …

Drug delivery of natural products through nanocarriers for effective breast cancer therapy: A comprehensive review of literature

KM Yap, M Sekar, S Fuloria, YS Wu… - International Journal …, 2021 - Taylor & Francis
Despite recent advances in the diagnosis and treatment of breast cancer (BC), it remains a
global health issue affecting millions of women annually. Poor prognosis in BC patients is …

Dietary compounds as epigenetic modulating agents in cancer

Á Carlos-Reyes, JS López-González… - Frontiers in …, 2019 - frontiersin.org
Epigenetic mechanisms control gene expression during normal development and their
aberrant regulation may lead to human diseases including cancer. Natural phytochemicals …

Epigallocatechin gallate: Phytochemistry, bioavailability, utilization challenges, and strategies

S Mehmood, M Maqsood, N Mahtab… - Journal of Food …, 2022 - Wiley Online Library
Epigallocatechin gallate (EGCG), a green tea catechin, has gained the attention of current
study due to its excellent health‐promoting effects. It possesses anti‐obesity, antimicrobial …

The role of epigenetic modifications in human cancers and the use of natural compounds as epidrugs: Mechanistic pathways and pharmacodynamic actions

A Bouyahya, H Mechchate, L Oumeslakht, I Zeouk… - Biomolecules, 2022 - mdpi.com
Cancer is a complex disease resulting from the genetic and epigenetic disruption of normal
cells. The mechanistic understanding of the pathways involved in tumor transformation has …

Flavonoids and other polyphenols act as epigenetic modifiers in breast cancer

P Selvakumar, A Badgeley, P Murphy, H Anwar… - Nutrients, 2020 - mdpi.com
Breast cancer is a common cancer that occurs due to different epigenetic alterations and
genetic mutations. Various epidemiological studies have demonstrated an inverse …

Molecular mechanisms of action of epigallocatechin gallate in cancer: Recent trends and advancement

V Aggarwal, HS Tuli, M Tania, S Srivastava… - Seminars in cancer …, 2022 - Elsevier
Epigallocatechin gallate (EGCG), also known as epigallocatechin-3-gallate, is an ester of
epigallocatechin and gallic acid. EGCG, abundantly found in tea, is a polyphenolic flavonoid …

Cancer preventive activities of tea catechins

CS Yang, H Wang - Molecules, 2016 - mdpi.com
Catechins are widely occurring in our diet and beverages. The cancer-preventive activities
of catechins have been extensively studied. Of these,(−)-epigallocatechin-3-gallate (EGCG) …