In recent years, tremendous progress has been made in understanding the mechanisms
underlying the specification of projection neurons within the mammalian neocortex. New …

Abstract In 1970 the Boulder Committee described the basic principles of the development
of the CNS, derived from observations on the human embryonic cerebrum. Since then …

Current models of somatosensory perception emphasize transmission from primary sensory
neurons to the spinal cord and on to the brain,,–. Mental influence on perception is largely …

Summary Cortical layer 5 (L5) pyramidal neurons integrate inputs from many sources and
distribute outputs to cortical and subcortical structures. Previous studies demonstrate two L5 …

Within the vertebrate nervous system, the presence of many different lineages of neurons
and glia complicates the molecular characterization of single neuronal populations. In order …

The cerebral neocortex is segregated into six horizontal layers, each containing unique
populations of molecularly and functionally distinct excitatory projection (pyramidal) neurons …

The selective elimination of axons, dendrites, axon and dendrite branches, and synapses,
without loss of the parent neurons, occurs during normal development of the nervous system …

Satb2 is a DNA-binding protein that regulates chromatin organization and gene expression.
In the developing brain, Satb2 is expressed in cortical neurons that extend axons across the …

Publisher Summary This chapter explores various questions: Are synapses added as we
learn? Are there more synapses in some cortical areas than in others? Are there gender …

A major hurdle for functional recovery after both spinal cord injury and cortical stroke is the
limited regrowth of the axons in the corticospinal tract (CST) that originate in the motor cortex …