Recent advances in local drug delivery to the inner ear
Inner ear diseases are not adequately treated by systemic drug administration mainly
because of the blood–perilymph barrier that reduces exchanges between plasma and inner …
because of the blood–perilymph barrier that reduces exchanges between plasma and inner …
New molecular therapies for the treatment of hearing loss
An estimated 466 million people suffer from hearing loss worldwide. Sensorineural hearing
loss is characterized by degeneration of key structures of the sensory pathway in the …
loss is characterized by degeneration of key structures of the sensory pathway in the …
Electrode array-eluted dexamethasone protects against electrode insertion trauma induced hearing and hair cell losses, damage to neural elements, increases in …
We evaluated the effects of dexamethasone base (DXMb) containing electrode arrays in a
guinea pig model of cochlear implantation to determine if eluted DXMb could protect the …
guinea pig model of cochlear implantation to determine if eluted DXMb could protect the …
Hearing preservation surgery for cochlear implantation: a meta-analysis
PL Santa Maria, MB Gluth, Y Yuan, MD Atlas… - Otology & …, 2014 - journals.lww.com
Objective To examine the results of hearing preservation in cochlear implantation surgery to
identify surgical technical factors, electrode array design factors, and steroid usage, which …
identify surgical technical factors, electrode array design factors, and steroid usage, which …
[HTML][HTML] Current strategies for drug delivery to the inner ear
H Liu, J Hao, KS Li - Acta Pharmaceutica Sinica B, 2013 - Elsevier
For many years, drug delivery to the inner ear has been a challenge to physicians in the
treatment of inner ear disorders. In the past decade, the field of inner ear drug delivery has …
treatment of inner ear disorders. In the past decade, the field of inner ear drug delivery has …
Overcoming barriers: a review on innovations in drug delivery to the middle and inner ear
DS Delaney, LJ Liew, J Lye, MD Atlas… - Frontiers in …, 2023 - frontiersin.org
Despite significant advances in the development of therapeutics for hearing loss, drug
delivery to the middle and inner ear remains a challenge. As conventional oral or …
delivery to the middle and inner ear remains a challenge. As conventional oral or …
Conservation of hearing and protection of hair cells in cochlear implant patients' with residual hearing
E Bas, CT Dinh, C Garnham, M Polak… - … Record: Advances in …, 2012 - Wiley Online Library
This review covers the molecular mechanisms involved in hair cell and hearing losses which
can result from trauma generated during the process of cochlear implantation and the …
can result from trauma generated during the process of cochlear implantation and the …
Cochlear implants: causes, effects and mitigation strategies for the foreign body response and inflammation
Cochlear implants provide effective auditory rehabilitation for patients with severe to
profound sensorineural hearing loss. Recent advances in cochlear implant technology and …
profound sensorineural hearing loss. Recent advances in cochlear implant technology and …
Dexamethasone eluting cochlear implant: Histological study in animal model
M Farhadi, M Jalessi, P Salehian, FF Ghavi… - Cochlear implants …, 2013 - Taylor & Francis
Objective New cochlear implant (CI) designs and developments in implantation techniques
have revolutionized the management of hearing loss. However, cochlear implantation still …
have revolutionized the management of hearing loss. However, cochlear implantation still …
High-precision 3D printing of microporous cochlear implants for personalized local drug delivery
Hearing loss is a highly prevalent multifactorial disorder affecting 20% of the global
population. Current treatments using the systemic administration of drugs are therapeutically …
population. Current treatments using the systemic administration of drugs are therapeutically …