Recent developments in 1, 6-addition reactions of para-quinone methides (p-QMs)

JY Wang, WJ Hao, SJ Tu, B Jiang - Organic Chemistry Frontiers, 2020 - pubs.rsc.org
In recent years, para-quinone methides (p-QMs) have emerged as attractive and versatile
synthons in organic synthesis owing to their high reactivity. Consequently, p-QM chemistry …

para‐Quinone Methides as Acceptors in 1,6‐Nucleophilic Conjugate Addition Reactions for the Synthesis of Structurally Diverse Molecules

CGS Lima, FP Pauli, DCS Costa… - European Journal of …, 2020 - Wiley Online Library
para‐Quinone methides (p‐QMs) are naturally occurring molecules that have been finding
increasing synthetic applications in the last few years. The presence of two electronically …

Reactivity of quinone methides with carbenes generated from α-diazocarbonyl compounds and related compounds

S Happy, M Junaid, D Yadagiri - Chemical Communications, 2023 - pubs.rsc.org
Over the years, quinone methides have broadly been applied in synthesis and biological
systems for synthesizing heterocyclic compounds and biologically active molecules. In this …

Multicomponent Synthesis of Biologically Relevant S‐Diarylmethane Dithiocarbamates Using p‐Quinone Methides

S Kumar Parida, S Kumar Hota… - Advanced Synthesis …, 2022 - Wiley Online Library
A metal and base‐free, operationally simple, and scalable multicomponent approach
towards the synthesis of S‐diarylmethane dithiocarbamates is reported. A range of …

1, 6-Addition of vinyl p-quinone methides with cyclic sulfamidate imines: access to 4-hydroxyaryl-2, 6-diarylpyridines

S Guin, SK Gudimella, S Samanta - Organic & Biomolecular Chemistry, 2020 - pubs.rsc.org
A simple and powerful one-pot regioselective 1, 6-addition elimination–6π-aza-
electrocyclization–aromatization reaction of vinyl/dienyl-substituted para-quinone methides …

The Bestmann‐Ohira Reagent and Related Diazo Compounds for the Synthesis of Azaheterocycles

MF Jamali, NK Vaishanv, K Mohanan - The Chemical Record, 2020 - Wiley Online Library
Azaheterocycles are one of the most prevalent classes of compounds present in numerous
bioactive compounds, natural products, and agrochemicals, and undoubtedly, new methods …

Base-Mediated 1, 6-Aza-Michael Addition of Heterocyclic Amines and Amides to para-Quinone Methides Leading to Meclizine-, Hydroxyzine-and Cetirizine-like …

D Roy, G Panda - Synthesis, 2019 - thieme-connect.com
An expeditious, cost-effective synthetic methodology for a wide range of nitrogen-containing
unsymmetrical trisubstituted methanes (TRSMs) is reported. The synthesis involves base …

1, 6-Aza-Michael addition of para-quinone methides with N-heterocycles catalyzed by Zn (OTf) 2: A regioselective approach to N-diarylmethyl-substituted heterocycles

S Guin, HK Saha, AK Patel, SK Gudimella, S Biswas… - Tetrahedron, 2020 - Elsevier
Abstract An efficient Zn (OTf) 2-catalyzed regioselective C–N bond making reaction between
a bunch of aryl/heteroaryl-substituted para-quinone methides as ideal 1, 6-acceptors and …

Stereoselective Synthesis of Tri- and Tetrasubstituted Olefins via 1,6-Additions of Diazo Compounds and Their Precursors to p-Quinone Methides

S Pati, S Rayi, INN Namboothiri - ACS Organic & Inorganic Au, 2021 - ACS Publications
Reactions of para-quinone methides (p-QMs) with α-diazo-β-ketosulfones and their
corresponding esters as well as simple β-dicarbonyl compounds and β-ketosulfones have …

Trifluoromethylnitrone: a versatile building block for synthesizing trifluoromethyl-containing heterocyclic compounds

M Abdulla, MK Hussain, S Ahamad - Organic & Biomolecular …, 2024 - pubs.rsc.org
This review explores the significance of trifluoromethylnitrones in synthesizing fluorine-
containing compounds, with a particular focus on trifluoromethylated heterocycles. It …