Phenylpyrazolone-1, 2, 3-triazole hybrids as potent antiviral agents with promising SARS-CoV-2 main protease inhibition potential
COVID-19 infection is now considered one of the leading causes of human death. As an
attempt towards the discovery of novel medications for the COVID-19 pandemic, nineteen …
attempt towards the discovery of novel medications for the COVID-19 pandemic, nineteen …
Synthesis and pesticidal activities of new quinoxalines
XH Liu, W Yu, LJ Min, DE Wedge, CX Tan… - Journal of Agricultural …, 2020 - ACS Publications
Natural products are a source of many novel compounds with biological activity for the
discovery of new pesticides and pharmaceuticals. Quinoxaline is a fused N-heterocycle in …
discovery of new pesticides and pharmaceuticals. Quinoxaline is a fused N-heterocycle in …
Novel scaffold hopping of potent benzothiazole and isatin analogues linked to 1, 2, 3-triazole fragment that mimic quinazoline epidermal growth factor receptor …
N Rezki, MA Almehmadi, S Ihmaid, AM Shehata… - Bioorganic …, 2020 - Elsevier
A series of benzothiazole/isatin linked to 1, 2, 3-triazole moiety and terminal sulpha drugs 5a-
e and 6a-e were synthesized and evaluated for cytotoxic activity against a panel of cancer …
e and 6a-e were synthesized and evaluated for cytotoxic activity against a panel of cancer …
Design, synthesis, antiproliferative evaluation, and molecular docking study of new quinoxaline derivatives as apoptotic inducers and EGFR inhibitors
A new series of quinoxaline derivatives synthesized and pharmacologically evaluated
against (HepG-2, HCT-116, and MCF-7) cell lines. Seven compounds were found to …
against (HepG-2, HCT-116, and MCF-7) cell lines. Seven compounds were found to …
The anticancer and EGFR-TK/CDK-9 dual inhibitory potentials of new synthetic pyranopyrazole and pyrazolone derivatives: X-ray crystallography, in vitro, and in silico …
Abstract Treatment options for the management of breast cancer are still inadequate. This
inadequacy is attributed to the lack of effective targeted medications, often resulting in the …
inadequacy is attributed to the lack of effective targeted medications, often resulting in the …
Design of molecular hybrids of phthalimide-triazole agents with potent selective MCF-7/HepG2 cytotoxicity: Synthesis, EGFR inhibitory effect, and metabolic stability
SK Ihmaid, SY Alraqa, MR Aouad, A Aljuhani… - Bioorganic …, 2021 - Elsevier
This study reports an efficient and convenient click chemistry synthesis of a novel series of
phthalimide scaffold linked to 1, 2, 3 triazole ring and terminal lipophilic fragments …
phthalimide scaffold linked to 1, 2, 3 triazole ring and terminal lipophilic fragments …
Design, Synthesis and Cytotoxic Evaluation of Novel Chalcone Derivatives Bearing Triazolo[4,3-a]-quinoxaline Moieties as Potent Anticancer Agents with Dual EGFR …
M Alswah, AH Bayoumi, K Elgamal, A Elmorsy… - Molecules, 2017 - mdpi.com
A series of hybrid of triazoloquinoxaline-chalcone derivatives 7a–k were designed,
synthesized, fully characterized, and evaluated for their cytotoxic activity against three target …
synthesized, fully characterized, and evaluated for their cytotoxic activity against three target …
Discovery of triaromatic flexible agents bearing 1, 2, 3-Triazole with selective and potent anti-breast cancer activity and CDK9 inhibition supported by molecular …
This study reports an efficient and convenient click synthesis of novel series of chromene
scaffold linked to 1, 2, 3 triazole ring and terminal lipophilic fragments. Structures of all newly …
scaffold linked to 1, 2, 3 triazole ring and terminal lipophilic fragments. Structures of all newly …
Exploring the dual effect of novel 1, 4-diarylpyranopyrazoles as antiviral and anti-inflammatory for the management of SARS-CoV-2 and associated inflammatory …
COVID-19 and associated substantial inflammations continue to threaten humankind
triggering death worldwide. So, the development of new effective antiviral and anti …
triggering death worldwide. So, the development of new effective antiviral and anti …
Lead-free Cs3Bi2Br9 perovskite: A recoverable heterogeneous photocatalyst for the C3 arylation of quinoxalin-2 (1H)-ones
SZ Zhang, LP Mo, ZH Zhang - Molecular Catalysis, 2024 - Elsevier
A facile, practical and attractive approach has been developed for the C3 arylation of
quinoxalin-2 (1H)-ones with phenylhydrazines using the lead-free perovskite Cs 3 Bi 2 Br 9 …
quinoxalin-2 (1H)-ones with phenylhydrazines using the lead-free perovskite Cs 3 Bi 2 Br 9 …